目的 探讨舒血宁注射液联合奥扎格雷治疗下肢骨折患者深静脉血栓的临床效果。方法 选取2014年1月-2016年12月在天津中医药大学第一附属医院接受治疗的120例下肢骨折术后发生下肢深静脉血栓患者，随机分为对照组（60例）和治疗组（60例）。对照组患者静脉滴注注射用奥扎格雷，80 mg加入到5%葡萄糖溶液250 mL，40滴/min，1次/d；治疗组患者在对照组的基础上静脉滴注舒血宁注射液，20 mL加入到生理盐水250 mL，40滴/min，1次/d，两组连续治疗14 d。观察两组的临床疗效，比较两组患者治疗后的凝血功能指标、血液流变学指标和不良反应的变化情况。结果 治疗后，治疗组患者的临床总有效率为93.3%，显著高于对照组的76.7%，两组比较差异具有统计学意义（P<0.05）。治疗后，两组患者的激活部分凝血活酶时间和凝血酶原时间显著升高，D-二聚体、纤维蛋白原显著降低，同组治疗前后差异具有统计学意义（P<0.05）；且治疗后治疗组患者的凝血功能指标明显优于对照组，两组比较差异具有统计学意义（P<0.05）；治疗后，两组患者的静脉血流速度显著升高，全血黏度显著降低，同组治疗前后差异具有统计学意义（P<0.05）；且治疗后治疗组患者的血液流变学指标明显优于对照组，两组比较差异具有统计学意义（P<0.05）。两组患者在治疗过程中未发生明显不良反应。结论 舒血宁注射液联合奥扎格雷治疗下肢骨折患者深静脉血栓具有良好的临床疗效，能够显著改善凝血功能和血液流变学指标，且不良反应少，具有一定的临床应用价值。

Objective To explore the effect of Shuxuening Injection combined with ozagrel in treatment of patients with lower limb deep vein thrombus after fracture of lower limb. Methods Patients (120 cases) with lower limb deep vein thrombus after fracture of lower limb in First Teaching Hospital of Tianjin University of TCM from from January 2014 to December 2016 were randomly divided into control (60 cases) and treatment (60 cases) groups. Patients in the control group were iv administered with Sodium Ozagrel for injection, 80 mg added into 5% glucose injection 250 mL, 40 drops/min, once daily. Patients in the treatment group were iv administered with Shuxuening Injection, 20 mL added into normal saline 250 mL, 40 drops/min, once daily. Patients in two groups were treated for 14 d. After treatment, the clinical efficacy was evaluated, and the changes of coagulative function indexes, hemodynamic indexes, and adverse reaction in two groups were compared. Results After treatment, the clinical efficacy in the treatment group was 93.3%, which was significantly higher than 76.7% in the control group, and the difference was statistically significant between two groups (P<0.05). After treatment, activated partial thromboplastin time and prothrombin time in two groups were significantly increased, but D-dimer and fibrinogen were significantly decreased, and the difference was statistically significant in the same group (P<0.05). And coagulative function index in the treatment group were better than those in the control group, and there was difference between two groups (P<0.05). After treatment, retinal rein velocity in two groups was significantly increased,blood viscosity was significantly decreased, and the difference was statistically significant in the same group (P<0.05). And hemodynamic indexes in the treatment group were better than those in the control group, and there was difference between two groups (P<0.05). There was no significant adverse reaction in two groups during the treatment. Conclusion Shuxuening Injection combined with ozagrel has a significant effect in treatment of patients with lower limb deep vein thrombus after fracture of lower limb and can significantly improve coagulative function indexes and hemodynamic indexes with less adverse reaction, which has a certain clinical application value.