目的 探讨阴道内置与舌下含化米索前列醇在门诊无痛人流中的应用疗效。方法 选取2015年11月-2016年11月深圳市龙华新区中心医院妇科门诊行无痛人流手术的孕早期妇女170例为研究对象，随机分为阴道内置组和舌下含化组，每组各85例。分别于术前3 h阴道内置与舌下含化米索前列醇片400 μg，再实施常规的无痛人工流产操作。观察两组的临床疗效，比较两组的手术时间、术中出血量及不良反应发生情况。结果 阴道内置组和舌下含化组的总有效率分别为96.47%、97.64%，两组总有效率比较差异无统计学意义；阴道内置组的手术时间短于舌下含化组，而阴道内置组的术中出血量多于舌下含化组，两组比较差异均无统计学意义。舌下含化组患者的术前阴道出血和下腹痛的发生率明显低于阴道内置组，两组比较差异具有统计学意义（P<0.05）。结论 米索前列醇通过阴道内置与舌下含化这两种给药途径均可以有效的扩张宫颈，特别是，舌下含化给药方式，用药方便、吸收效果好，避免了阴道内置给药的不便和相关不良反应，一般情况下可首选，而对于妊娠反应重或不适合舌下含化的患者，更适宜选择阴道内置给药方式，故医师在临床用药时可根据患者的实际情况选择合适的给药途径。

Objective To explore the curative effect of vaginal implantation and sublingual misoprostol in outpatient painless flow. Methods Early pregnancy women (170 cases) with painless flow in Department of Gynecology in Shenzhen Longhua New District Central Hospital from November 2015 to November 2016 were randomly divided into vaginal implantation and sublingual groups, and each group had 85 cases. Patients were vaginal implantation and sublingual with Misoprostol Tablets, 400 μg, respectively. Then they were given the implementation of conventional painless abortion. The clinical efficacies were evaluated, and operation time, peroperative bleeding volum, and adverse reaction in two groups were compared. Results The clinical efficacies in the control and treatment groups were 96.47% and 97.64%, respectively, and there was no difference between two groups. Operation time in vaginal implantation group was lower than that in the treatment group, while peroperative bleeding volum in vaginal implantation group was more than that in the treatment group, but there was no significant difference between two groups. The occurrence rate of preoperative vaginal bleeding in vaginal implantation groups and lower abdominal pain were lower than those in sublingual group, and there was difference between two groups (P<0.05). Conclusion Misoprostol can effectively expand the cervix through vaginal implantation and sublingual administration. In particular, the sublingual administration is convenient with good absorption, and it can avoid the inconvenience of vaginal implantation and related adverse reactions, which can be preferred. For patients with serious pregnancy reaction or those unsuitable for sublingual, it is more appropriate to choose vaginal implantation. Therefore, physician choose appropriate route of administration according to the actual situation of patients in the clinical medication.