目的 探讨甘草甜素片联合注射用丁二磺酸腺苷蛋氨酸治疗肝内胆汁淤积性肝炎的临床疗效。方法 选取2015年1月-2017年1月陕西省人民医院收治的肝内胆汁淤积性肝炎患者64例作为研究对象，所有患者随机分为对照组和治疗组，每组各32例。对照组静脉滴注注射用丁二磺酸腺苷蛋氨酸，1.0 g加入到15%葡萄糖溶液250 mL中，1次/d。治疗组在对照组基础上口服甘草甜素片，150 mg/次，2次/d。两组患者均连续治疗4周。观察两组的临床疗效，比较两组的症状改善和肝功能情况。结果 治疗后，对照组和治疗组的总有效率分别为78.1%、96.9%，两组比较差异有统计学意义（P<0.05）。治疗后，两组乏力、恶心呕吐、腹胀、灰白便、皮肤瘙痒的比例均明显下降，同组治疗前后比较差异有统计学意义（P<0.05）；且治疗组这些观察指标明显低于对照组，两组比较差异具有统计学意义（P<0.05）。治疗后，两组丙氨酸氨基转移酶（ALT）、血清总胆红素（TBIL）、γ-谷氨酰转移酶（γ-GT）、碱性磷酸酶（ALP）、总胆汁酸（TBA）水平均明显降低，同组治疗前后比较差异有统计学意义（P<0.05）；且治疗组这些观察指标明显低于对照组，两组比较差异具有统计学意义（P<0.05）。结论 甘草甜素片联合注射用丁二磺酸腺苷蛋氨酸治疗肝内胆汁淤积性肝炎具有较好的临床疗效，可改善临床症状和肝功能指标，具有一定的临床推广应用价值。

Objective To investigate the efficacy of Glycyrrhizin Tablets combined with Ademetionine 1,4-Butanedisulfonate for injection in treatment of intrahepatic cholestasis hepatitis. Methods Patients (64 cases) with intrahepatic cholestasis hepatitis in Shaanxi Provincial People's Hospital from January 2015 to January 2017 were randomly divided into control and treatment groups, and each group had 32 cases. Patients in the control group were iv administered with Ademetionine 1,4-Butanedisulfonate for injection, 1.0 g added into 15% glucose solution 250 mL, once daily. Patients in the treatment group were po administered with Glycyrrhizin Tablets on the basis of the control group, 150 mg/time, twice daily. Patients in two groups were treated for 4 weeks. After treatment, the clinical efficacies were evaluated, and symptom improvement and liver function in two groups before and after treatment were compared. Results After treatment, the clinical efficacies in the control and treatment groups were 78.1% and 96.9%, respectively, and there was difference between two groups (P<0.05). After treatment, the proportion of fatigue, nausea, vomiting, abdominal distension, gray stools, and skin itch in two groups were significantly decreased, and the difference was statistically significant in the same group (P<0.05). And the observational indexes in the treatment group were significantly lower than those in the control group, with significant difference between two groups (P<0.05). After treatment, the levels of ALT, TBIL, γ-GT, ALP, and TBA in two groups were significantly decreased, and the difference was statistically significant in the same group (P<0.05). And the observational indexes in the treatment group were significantly lower than those in the control group, with significant difference between two groups (P<0.05). Conclusion Glycyrrhizin Tablets combined with Ademetionine 1,4-Butanedisulfonate for injection has clinical curative effect in treatment of intrahepatic cholestasis hepatitis, can improve clinical symptom and liver function, which has a certain clinical application value.