目的 探讨注射用盐酸头孢吡肟联合注射用替加环素治疗克雷伯菌肺炎的临床疗效。方法 回顾分析2015年2月-2016年2月在河南省人民医院进行治疗的109例克雷伯菌肺炎患者，所有患者分为对照组（54例）和治疗组（55例）。对照组静脉滴注注射用替加环素，首次剂量100 mg，然后调整为50 mg/次，1次/12 h。治疗组在对照组的基础上静脉注射注射用盐酸头孢吡肟，2 g/次，1次/12 h。所有患者均连续治疗1周。观察两组的临床疗效，比较两组的病原菌清除率、体温以及实验室指标。结果 治疗后，对照组和治疗组的总有效率分别为81.48%、96.36%，两组比较差异具有统计学意义（P<0.05）。治疗后，对照组和治疗组的病原菌清除率分别为83.33%、98.18%，两组比较差异有统计学意义（P<0.05）。治疗后，两组体温、C-反应蛋白和降钙素原均显著降低，而中性粒细胞百分比均显著升高，同组治疗前后比较差异有统计学意义（P<0.05）；且治疗组这些观察指标的改善程度明显优于对照组，两组比较差异具有统计学意义（P<0.05）。结论 注射用盐酸头孢吡肟联合注射用替加环素治疗克雷伯菌肺炎具有较好的临床疗效，可降低C-反应蛋白和降钙素原水平，升高中性粒细胞百分比，安全性较好，具有一定的临床推广应用价值。

Objective To investigate the clinical efficacy of Cefepime Hydrochloride for injection combined with Tigecycline for injection in treatment of klebsiella pneumonia. Methods Patients (109 cases) with klebsiella pneumonia in Henan Province People's Hospital from February 2015 to February 2016 were randomly divided into the control group (54 cases) and treatment group (55 cases). Patients in the control group were iv administered with Tigecycline for injection, first dose 100 mg, then adjust to 50 mg/time, once every 12 hours. Patients in the treatment group were iv administered with Cefepime Hydrochloride for injection on the basis of the control group, 2 g/time, once every 12 hours. Patients in two groups were treated for 1 week. After treatment, the clinical efficacies were evaluated, and clearance rate of pathogens, body temperature and laboratory indexes in two groups were compared. Results After treatment, the clinical efficacies in the control and treatment groups were 81.48% and 96.36%, and the clearance rates of pathogens in the control and treatment groups were 83.33% and 98.18%, respectively, and there was difference between two groups (P<0.05). After treatment, body temperature, C-reactive protein, and procalcitonin in two groups were significantly decreased, but the percentage of neutrophils in two groups were significantly increased, and the difference was statistically significant in the same group (P<0.05). And the observational indexes in the treatment group were significantly better than those in the control group, with significant difference between two groups (P<0.05). Conclusion Cefepime Hydrochloride for injection combined with Tigecycline for injection has curative effect in treatment of klebsiella pneumonia, can decrease C-reactive protein and procalcitonin levels, and increase the percentage of neutrophils, with good safety, which has a certain clinical application value.