乳腺癌已成为危及女性生命健康最常见的恶性肿瘤之一，若能实现对其进行早期诊断并积极干预，会极大提高患者的生存率。近几十年来，核素功能成像特别是PET成像显著提高了对乳腺癌各种生物学过程的认识能力，为从分子及细胞水平准确地诊断乳腺癌提供了可能。目前已有多种乳腺癌PET分子探针被开发，对代谢类、细胞增殖类、雌激素α受体类、雌激素β受体类、孕激素受体类、表皮生长因子类、胃泌素释放肽类、乏氧类、氨基转运类PET分子探针的研究进展进行综述。

Breast cancer has become a sever disease that threats to women's health. Early diagnosis and positive intervention of breast cancer will greatly increase the survival rate of patients. In recent decades, radionuclide functional imaging, especially PET imaging, has significantly improved the understanding of various biological processes in breast cancer, and has made the accurate diagnosis of breast cancer at the molecular and cellular levels possible. Research advances ofn PET molecular probes of metabolic, cell proliferation, estrogen receptor α, estrogen receptor β, progesterone receptor, epidermal growth factor, gastrin-releasing peptide receptor, hypoxia, amino transport are reviewed in this paper.

湖北省教育厅科学研究计划指导性项目（B2017578）