目的 探讨盐酸阿米替林片联合琥珀酸索利那新片治疗老年女性膀胱过度活动症的临床效果。方法 选择2010年5月-2016年2月十堰市人民医院泌尿外科收治的老年女性膀胱过度活动症患者50例为研究对象，所有患者按照疾病严重程度随机分为对照组和治疗组，每组各25例。对照组口服琥珀酸索利那新片，5 mg/次，1次/d，治疗组在对照组基础上口服盐酸阿米替林片，25 mg/次，2次/d。两组均连续治疗2个月。观察两组的临床疗效，比较两组的日排尿次数、夜尿次数、尿急次数、急迫性尿失禁次数等完善膀胱过度活动症症状评分（OABSS）情况。结果 治疗后，对照组和治疗组的总有效率分别为64.0%、80.0%，两组比较差异有统计学意义（P<0.05）。治疗后，两组日排尿次数、尿急次数、急迫性尿失禁次数评分均显著降低，同组治疗前后比较差异有统计学意义（P<0.05）；且治疗组这些指标明显低于对照组，两组比较差异具有统计学意义（P<0.05）。结论 盐酸阿米替林片联合琥珀酸索利那新片治疗老年女性膀胱过度活动症具有较好的临床疗效，可改善临床症状，安全性较好，具有一定的临床推广应用价值。

Objective To investigate the clinical effect of Amitriptyline Hydrochloride Tablets combined with Solifenacin Succinate Tablets in treatment of overactive bladder in senile women. Methods Elderly women (50 cases) with overactive bladder in Department of Urinary Surgery of Shiyan People's Hospital from May 2010 to February 2016 were enrolled in this study. According to the disease severity, patients were randomly divided into control and treatment groups, and each group had 25 cases. Patients in the control group were po administered with Solifenacin Succinate Tablets, 5 mg/time, once daily. Patients in the treatment group were po administered with Amitriptyline Hydrochloride Tablets on the basis of the control group, 25 mg/time, twice daily. Patients in two groups were treated for 2 months. After treatment, the clinical efficacies were evaluated, and OABSS score, such as daily urination times, nocturia times, urgency times, and urinary incontinence times in two groups were compared. Results After treatment, the clinical efficacies in the control and treatment groups were 64.0% and 80.0%, respectively, and there was difference between two groups (P<0.05). After treatment, the scores of daily urination times, urgency times, and urinary incontinence times in two groups were significantly decreased, and the difference was statistically significant in the same group (P<0.05). And the observational indexes in the treatment group were significantly lower than those in the control group, with significant difference between two groups (P<0.05). Conclusion Amitriptyline Hydrochloride Tablets combined with Solifenacin Succinate Tablets has clinical curative effect in treatment of overactive bladder in senile women, can improve clinical symptoms, with good safety, which has a certain clinical application value.