目的 探讨巴曲酶注射液联合地塞米松磷酸钠注射液治疗突发性耳聋的临床疗效。方法 选取2014年6月-2016年7月南京医科大学第二附属医院收治的突发性耳聋患者60例为研究对象，根据随机分组法将60例患者分为对照组和治疗组，每组各30例。对照组采用鼓室内注射地塞米松磷酸钠注射液，5 mg/次，3次/周。治疗组在对照组基础上静脉滴注巴曲酶注射液，10 BU加入到生理盐水100 mL中，1次/2 d，自第2天复查凝血指标，若纤维蛋白原（FIB）>1.0，则用量减半。两组患者均连续治疗7 d。观察两组的临床疗效，比较两组不同程度耳聋有效率、凝血功能指标和血流动力学指标。结果 治疗后，对照组和治疗组的总有效率分别为70.0%、83.3%，两组比较差异有统计学意义（P<0.05）。治疗后，治疗组中度、中重度、重度耳聋患者治疗有效率均显著高于对照组，两组比较差异有统计学意义（P<0.05）。治疗后，两组凝血酶时间（TT）、凝血酶原时间（PT）、活化部分凝血酶原时间（ATPP）均明显上升，而FIB均显著下降，同组治疗前后比较差异有统计学意义（P<0.05）；且治疗组这些观察指标的改善程度明显优于对照组，两组比较差异具有统计学意义（P<0.05）。治疗后，两组血浆黏度（PV）、全血黏度高切黏度（HS）、中切黏度（MS）和低切黏度（LS）均明显降低，同组治疗前后比较差异有统计学意义（P<0.05）；且治疗组这些观察指标明显低于对照组，两组比较差异具有统计学意义（P<0.05）。结论 巴曲酶注射液联合地塞米松磷酸钠注射液治疗突发性耳聋具有较好的临床疗效，可改善凝血指标和血流动力学指标，安全性较好，具有一定的临床推广应用价值。

Objective To investigate the effect of Batroxobin Injection combined with Dexamethasone Sodium Phosphate Injection in treatment of sudden deafness. Methods Patients (60 cases) with sudden deafness in the Second Affiliated Hospital of Nanjing Medical University from June 2014 to July 2015 were randomly divided into control and treatment groups, and each group had 30 cases. Patients in the control group were intratympanic injection administered with Dexamethasone Sodium Phosphate Injection, 5 mg/time, three times weekly. Patients in the treatment group were iv administered with Batroxobin Injection on the basis of the control group, 10 BU added into normal saline 100 mL, every other day, review coagulation index since the second day, if FIB > 1.0, dosage halved. Patients in two groups were treated for 7 d. After treatment, the clinical efficacies were evaluated, and the clinical efficacies of deafness of different degrees, coagulation function indexes, hemodynamic indexes in two groups were compared. Results After treatment, the clinical efficacies in the control and treatment groups were 70.0% and 83.3%, respectively, and there was difference between two groups (P<0.05). After treatment, the clinical efficacies of deafness of moderate, moderate to severe, and severe in the treatment group were significantly higher than those in the control group, and there was difference between two groups (P<0.05). After treatment, TT, PT, and ATPP in two groups were significantly increased, but the FIB in two groups were significantly decreased, and the difference was statistically significant in the same group (P<0.05). And the observational indexes in the treatment group were significantly better than those in the control group, with significant difference between two groups (P<0.05). After treatment, PV, HS, MS, and LS in two groups were significantly decreased, and the difference was statistically significant in the same group (P<0.05). And the observational indexes in the treatment group were significantly lower than those in the control group, with significant difference between two groups (P<0.05). Conclusion Batroxobin Injection combined with Dexamethasone Sodium Phosphate Injection has clinical curative effect in treatment of sudden deafness, can improve coagulation function index and hemodynamic index, with good safety, which has a certain clinical application value.