目的 探讨鼓室注射与静脉滴注甲泼尼龙琥珀酸钠治疗突发性耳聋的临床疗效。方法 选取2015年1月—2016年3月如东县人民医院收治的突发性耳聋患者86例，所有患者按随机数字表法分为对照组和治疗组，每组各43例，各43耳。对照组静脉滴注注射用甲泼尼龙琥珀酸钠，0.8 mg/kg加入到5%葡萄糖溶液250 mL中，1次/d，滴注时间> 30 min，连续用药5 d后逐日递减8 mg至第10天停药。治疗组鼓室注射注射用甲泼尼龙琥珀酸钠，40 mg与稀释液混合，1次/2 d，治疗5次。观察两组的临床疗效，比较两组的听力平均阈值和并发症疗效。结果 治疗后，对照组和治疗组的总有效率分别为60.46%、83.72%，两组比较差异有统计学意义（P< 0.05）。治疗后，两组0.25、0.5、1、2、4、8 kHz的听力平均阈值均显著降低，同组治疗前后比较差异有统计学意义（P< 0.05）；且治疗组这些观察指标明显低于对照组，两组比较差异具有统计学意义（P< 0.05）。治疗后，对照组和治疗组耳鸣有效率分别为58.62%、83.87%，耳闷有效率分别为52.63%、83.34%，眩晕有效率分别为61.11%、89.47%，两组并发症有效率比较差异有统计学意义（P< 0.05）。结论 鼓室注射与静脉滴注甲泼尼龙琥珀酸钠治疗突发性耳聋具有较好的疗效，鼓室注射给药在提高听力阈值、治疗并发症方面优于静脉滴注给药，安全性好，具有一定的临床推广应用价值。

Objective To investigate the clinical effect of intratympanic injection and intravenous injection of methylprednisolone sodium succinate in treatment of sudden deafness. Methods Patients (86 cases) with sudden deafness in Rudong County People's Hospital from January 2015 to March 2016 were randomly divided into control and treatment groups, and each group had 43 cases or 43 ears. Patients in the control group were iv administered with Methylprednisolone Sodium Succinate for injection, 0.8 mg/kg added into 5% glucose solution 250 mL, once daily, drip time >30 min, and after treatment for 5 d, decreased by 8 mg daily until the tenth day to stop drug. Patients in the treatment group were intratympanic injection administered with Methylprednisolone Sodium Succinate for injection, 40 mg mixed with dilute solution, once every 2 d, 5 times of treatment. After treatment, the clinical efficacies were evaluated, and average hearing threshold and efficacies of complication in two groups were compared. Results After treatment, the clinical efficacies in the control and treatment groups were 60.46% and 83.72%, respectively, and there was difference between two groups (P < 0.05). After treatment, average hearing threshold of 0.25, 0.5, 1, 2, 4, and 8 kHz in two groups were significantly decreased, and the difference was statistically significant in the same group (P < 0.05). And the observational indexes in the treatment group were significantly lower than those in the control group, with significant difference between two groups (P < 0.05). After treatment, the efficacies of tinnitus, aural fullness, and vertigo in the control and treatment groups were 58.62% and 83.87%, 52.63% and 83.34%, and 61.11% and 89.47%, respectively, and there were difference between two groups (P < 0.05). Conclusion Intratympanic injection and intravenous injection of methylprednisolone sodium succinate has clinical curative effect in treatment of sudden deafness, the administration of intratympanic injection in increasing hearing threshold and treating complications was better than the administration of intravenous infusion, with good safety, which has a certain clinical application value.