目的 探讨芪苈强心胶囊联合吲达帕胺治疗高血压心力衰竭的临床疗效。方法 选取2016年1月—2017年1月在桐柏县中医院进行治疗的88例高血压心力衰竭患者，随机分为对照组（44例）和治疗组（44例）；对照组口服吲达帕胺片，2.5 mg/次，1次/d。治疗组在对照组的基础上口服芪苈强心胶囊，4粒/次，3次/d。两组患者均连续治疗8周。治疗后，观察两组患者临床疗效，同时比较治疗前后两组心功能和6 min步行试验（6WMT）、血清学指标及不良反应。结果 治疗后，对照组和治疗组的总有效率分别为79.55%、95.45%，两组比较差异有统计学意义（P< 0.05）。治疗后，两组左心室收缩末期内径（LVDS）、左心室舒张末期内径（LVEDD）均显著降低，左室射血分数（LVEF）、6WMT均明显增加，同组治疗前后比较差异具有统计学意义（P< 0.05）；且治疗组上述观察指标显著优于对照组，两组比较差异具有统计学意义（P< 0.05）。治疗后，两组患者血清hs-CRP、β-EP、NT-proBNP和CT-1水平均显著降低，同组治疗前后比较差异具有统计学意义（P< 0.05）；且治疗组上述指标显著低于对照组，两组比较差异具有统计学意义（P< 0.05）。两组均无明显不良反应发生。结论 芪苈强心胶囊联合吲达帕胺治疗高血压心力衰竭疗效显著，有利于患者心功能及机体细胞因子的改善，具有一定的临床推广应用价值。

Objective To observe the therapeutic effect of Qili Qiangxin Capsules combined with indapamide in treatment of hypertensive heart failure. Methods Patients (88 cases) with hypertensive heart failure in Tongbai Hospital of TCM from January 2016 to January 2017 were randomly divided into control (44 cases) and treatment groups (44 cases). Patients in the control group were po administered with Indapamide Tablets, 2.5 mg/time, once daily. Patients in the treatment group were po administered with Qili Qiangxin Capsules, four grains/time, three times daily. Patients in two groups were treated for 8 weeks. After treatment, the clinical efficacy was evaluated, and cardiac function, 6WMT, serum indexes, and adverse reactions in two groups before and after treatment were compared.Results After treatment, the clinical efficacies in the control and treatment groups were 79.55% and 95.45%, respectively, and there was difference between two groups (P < 0.05). After treatment, LVDS and LVEDD in two groups significantly decreased, but LVEF and 6WMT significantly increased, and the difference was statistically significant in the same group (P < 0.05). And those indexes in the treatment group were significantly better than those in the control group, with significant difference between two groups (P < 0.05). After treatment, the levels of hs-CRP, β-EP, NT-proBNP, and CT-1 in serum in two groups significantly decreased, and the difference was statistically significant in the same group (P < 0.05). And those indexes in the treatment group were significantly lower than those in the control group, with significant difference between two groups (P < 0.05). There were no adverse reactions in two groups. Conclusion Qili Qiangxin Capsules combined with indapamide has a significant curative effect in treatment of hypertensive heart failure, can significantly improve the cardiac function and cytokines levels, which has a certain clinical application value.