目的 探讨注射用胸腺肽α₁联合注射用替加环素治疗多重耐药鲍曼不动杆菌肺炎的临床疗效。方法 选取2015年9月—2016年9月在漯河市中心医院呼吸内科接受治疗的多重耐药鲍曼不动杆菌肺炎患者84例，根据治疗方案的差别分为对照组和治疗组，每组各42例。对照组静脉滴注注射用替加环素，首剂100 mg，加入到0.9%氯化钠溶液100 mL中，然后50 mg，1次/12 h。治疗组在对照组基础上皮下注射注射用胸腺肽α₁，1.6 mL加入到0.9%氯化钠溶液1 mL中，1次/d，1周后改为2次/周。两组患者均连续治疗14 d。观察两组的临床疗效，比较两组的临床症状消失时间和血清学指标。结果 治疗后，对照组和治疗组的总有效率分别为80.95%、97.62%，两组比较差异有统计学意义（P < 0.05）。治疗后，治疗组体温恢复正常时间、咳嗽消失时间和肺部啰音消失时间明显短于对照组，两组比较差异有统计学意义（P < 0.05）。治疗后，两组血清碱性成纤维细胞生长因子（bFGF）、降钙素原（PCT）和髓系细胞可溶性触发受体1（sTREM-1）水平均明显降低，而白细胞介素-10（IL-10）水平均明显升高，同组治疗前后比较差异有统计学意义（P < 0.05）；且治疗组这些观察指标的改善程度明显优于对照组，两组比较差异具有统计学意义（P < 0.05）。结论 注射用胸腺肽α₁联合注射用替加环素治疗多重耐药鲍曼不动杆菌肺炎具有较好的临床疗效，可改善临床症状，调节血清学指标，具有一定的临床推广应用价值。

Objective To investigate the clinical effect of Thymalfasin for injection combined with Tigecycline for injection in treatment of multidrug resistant acinetobacter baumannii pneumonia. Methods Patients (84 cases) with multidrug resistant acinetobacter baumannii pneumonia in Department of Respiratory Medicine of Luohe Central Hospital from September 2015 to September 2016 were enrolled in this study. According to the difference treatment plan, patients were divided into control and treatment groups, and each group had 42 cases. Patients in the control group were iv administered with Tigecycline for injection, first dosage 100 mg added into normal saline 100 mL, then dose adjustment to 50 mg, once every 12 h. Patients in the treatment group were subcutaneous injection administered with Thymalfasin for injection on the basis of the control group, 1.6 mL added into normal saline 1 mL, once daily. Patients in two groups were treated for 14 d. After treatment, the clinical efficacies were evaluated, and clinical symptom disappearance time and serological indexes in two groups were compared. Results After treatment, the clinical efficacies in the control and treatment groups were 80.95% and 97.62%, respectively, and there was difference between two groups (P < 0.05). After treatment, body temperature recovery time, cough disappearance time, and lung rales disappearance time in the treatment group were shorter than those in the control group, and there was difference between two groups (P < 0.05). After treatment, the levels of bFGF, PCT, and sTREM-1 in two groups were significantly decreased, but the levels of IL-10 in two groups were significantly increased, and the difference was statistically significant in the same group (P < 0.05). And the observational indexes in the treatment group were significantly better than those in the control group, with significant difference between two groups (P < 0.05). Conclusion Thymalfasin for injection combined with Tigecycline for injection has clinical curative effect in treatment of multidrug resistant acinetobacter baumannii pneumonia, can improve clinical symptoms, and regulate serological index, which has a certain clinical application value.