目的 探讨胆宁片联合多烯磷脂酰胆碱胶囊治疗非酒精性脂肪肝的临床疗效。方法 收集2015年4月-2016年4月在上海杨浦区五角场街道社区卫生服务中心进行治疗的非酒精性脂肪肝病患者88例，随机分为对照组（44例）和治疗组（44例）。对照组口服多烯磷脂酰胆碱胶囊，2粒/次，3次/d。治疗组在对照组的基础上口服胆宁片，5片/次，3次/d。两组患者均连续治疗6个月。评价两组患者临床疗效，同时比较两组治疗前后血脂水平和肝功能改变。结果 治疗后，对照组和治疗组总有效率分别为81.82%、97.73%，两组总有效率比较差异有统计学意义（P<0.05）。治疗后，两组患者三酰甘油（TG）、总胆固醇（TC）、低密度脂蛋白（LDL-C）水平均显著降低，而高密度脂蛋白（HDL-C）则明显升高，同组治疗前后比较差异具有统计学意义（P<0.05）；且治疗组患者上述血脂水平改善程度优于对照组，两组比较差异具有统计学意义（P<0.05）。治疗后，两组患者丙氨酸氨基转移酶（ALT）、天冬氨酸氨基转移酶（AST）和γ-谷氨酰转移酶（γ-GT）水平均比同组治疗前显著降低，同组比较差异具有统计学意义（P<0.05）；且治疗组患者肝功能改善程度显著优于对照组，两组比较差异具有统计学意义（P<0.05）。结论 胆宁片联合多烯磷脂酰胆碱胶囊治疗非酒精性脂肪肝效果显著，可明显降低患者血脂水平，具有一定的临床推广应用价值。

Objective To investigate the clinical effect of Danning Tablets combined with Polyene Phosphatidylcholine Capsules in treatment of nonalcoholic fatty liver disease. Methods Patients (88 cases) with nonalcoholic fatty liver disease in Shanghai Yangpu District Wujiaochang Street Community Health Service Center from April 2015 to April 2016 were randomly divided into control (44 cases) and treatment (44 cases) groups. Patients in the control group were po administered with Polyene Phosphatidylcholine Capsules, 2 grains/time, three times daily. Patients in the treatment group were po administered with Danning Tablets on the basis of the control group, 5 tablets/time, three times daily. Patients in two groups were treated for 6 months. After treatment, the clinical efficacy was evaluated, and blood lipid level and liver function in two groups before and after treatment were compared. Results After treatment, the clinical efficacies in the control and treatment groups were 81.82% and 97.73%, respectively, and there was difference between two groups (P<0.05). After treatment, TG, TC, and LDL-C levels in two groups were significantly decreased, but HDL-C was significantly increased, and the difference was statistically significant in the same group (P<0.05). And the blood lipid level in the treatment group was significantly better than that in the control group, with significant difference between two groups (P<0.05). After treatment, ALT, AST, and γ-GT levels in two groups were significantly decreased, and there was difference in the same group (P<0.05). And the improvement degree of liver function in the treatment group was significantly better than that in the control group, with significant difference between two groups (P<0.05). Conclusion Danning Tablets combined with Polyene Phosphatidylcholine Capsules has significant effect in treatment of nonalcoholic fatty liver disease, and can significantly reduce the blood lipid level, which has a certain clinical application value.