目的 探讨腰痛宁胶囊治疗腰椎骨质增生症的临床疗效。方法 选取2015年7月-2016年8月在河南省荣军医院接受治疗的腰椎骨质增生症患者98例，根据治疗方法的不同分为对照组和治疗组，每组各49例。对照组给予腰部按摩、止痛等常规治疗。治疗组在对照组基础上口服腰痛宁胶囊，6粒/次，1次/d。两组患者均治疗8周。观察两组的临床疗效，比较两组血清学指标、视觉模拟评分法（VAS）评分和Oswestry功能障碍指数问卷表（ODI）评分情况。结果 治疗后，对照组和治疗组的总有效率分别为79.59%、95.92%，两组比较差异有统计学意义（P<0.05）。治疗后，两组血清转化生长因子-β₁（TGF-β₁）、Dickkopf-1（DKK1）和硬化蛋白（SOST）均显著升高，同组治疗前后比较差异有统计学意义（P<0.05）；且治疗组这些观察指标的升高程度明显优于对照组，两组比较差异具有统计学意义（P<0.05）。治疗后，两组VAS评分和ODI评分均显著降低，同组治疗前后比较差异有统计学意义（P<0.05）；且治疗组这些观察指标的下降程度明显优于对照组，两组比较差异具有统计学意义（P<0.05）。结论 腰痛宁胶囊治疗腰椎骨质增生症具有较好的临床疗效，可明显改善临床症状，调节血清学指标，具有一定的临床推广应用价值。

Objective To investigate the clinical effect of Yaotongning Capsules in treatment of lumbar vertebral bone hyperplasia. Methods Patients (98 cases) with lumbar vertebral bone hyperplasia in Henan Rongjun Hospital from July 2015 to August 2016 were enrolled in this study. According to the difference treatment plan, patients were divided into control and treatment groups, and each group had 49 cases. Patients in the control group were given conventional treatment such as lumbar massage and pain relief. Patients in the treatment group were po administered with Yaotongning Capsules on the basis of the control group, 6 grains/time, once daily. Patients in two groups were treated for 8 weeks. After treatment, the clinical efficacies were evaluated, and serological indexes, VAS scores, and ODI scores in two groups were compared. Results After treatment, the clinical efficacies in the control and treatment groups were 79.59% and 95.92%, respectively, and there was difference between two groups (P<0.05). After treatment, TGF-β₁, DKK1, and SOST in two groups were significantly increased, and the difference was statistically significant in the same group (P<0.05). And the observational indexes in the treatment group were significantly higher than those in the control group, with significant difference between two groups (P<0.05). After treatment, VAS scores and ODI scores in two groups were significantly decreased, and the difference was statistically significant in the same group (P<0.05). And the observational indexes in the treatment group were significantly lower than those in the control group, with significant difference between two groups (P<0.05). Conclusion Yaotongning Capsules has clinical curative effect in treatment of lumbar vertebral bone hyperplasia, can improve clinical symptoms, and regulate serological indexes, which has a certain clinical application value.