目的 探讨黄连解毒丸联合利巴韦林治疗小儿疱疹性口炎的临床疗效。方法 选取2014年2月-2016年2月宝鸡市妇幼保健院收治的小儿疱疹性口炎患儿92例，随机分为对照组和治疗组，每组各46例。对照组超声雾化吸入利巴韦林注射液，10 mg/kg加入到生理盐水10 mL中，2次/d。治疗组在对照组基础上口服黄连解毒丸，6丸/次，2次/d。两组患者均治疗7 d。观察两组的临床疗效，比较两组症状缓解时间、免疫球蛋白（IgG、IgA、IgM）和T细胞亚群（CD3⁺、CD4⁺、CD8⁺）情况。结果 治疗后，对照组和治疗组的总有效率分别为87.0%、97.8%，两组比较差异有统计学意义（P<0.05）。治疗后，治疗组发热、非正常进食、口腔疱疹和流涎的症状缓解时间均明显短于对照组，两组比较差异有统计学意义（P<0.05）。治疗第4、5、6、7天后，对照组IgG、IgA、IgM、CD3⁺、CD4⁺和CD8⁺水平均显著升高，而治疗第1、2、3、4、5、6、7天后，治疗组IgG、IgA、IgM、CD3⁺、CD4⁺和CD8⁺水平均显著升高，同组治疗前后比较差异有统计学意义（P<0.05）；且治疗组这些观察指标的升高程度明显优于对照组，两组比较差异具有统计学意义（P<0.05）。结论 黄连解毒丸联合利巴韦林治疗小儿疱疹性口炎具有较好的临床疗效，可改善临床症状，提高患儿免疫力，具有一定的临床推广应用价值。

Objective To explore the clinical effect of Huanglian Jiedu Pills combined with ribavirin in treatment of pediatric herpetic stomatitis. Methods Children (92 cases) with pediatric herpetic stomatitis in Maternal and Child Health Hospital of Baoji from February 2014 to February 2016 were randomly divided into control and treatment groups, and each group had 46 cases. Children in the control group were ultrasonic atomizing inhalation administered with Ribavirin Injection, 10 mg/kg added into normal saline 10 mL, twice daily. Children in the treatment group were po administered with Huanglian Jiedu Pills on the basis of the control group, 6 pills/time, twice daily. Children in two groups were treated for 7 d. After treatment, the clinical efficacies were evaluated, and symptom relief time, immunoglobulin (IgG, IgA, IgM), and T cell subsets (CD3⁺, CD4⁺, CD8⁺) in two groups were compared. Results After treatment, the clinical efficacies in the control and treatment groups were 87.0% and 97.8%, respectively, and there was difference between two groups (P<0.05). After treatment, the symptom relief times of fever, non-normal eating, oral herpes, and ptyalism in the treatment group were shorter than those in the control group, and there was difference between two groups (P<0.05). After treatment for 4, 5, 6, and 7 d, the levels of IgG, IgA, IgM, CD3⁺, CD4⁺, and CD8⁺in the control group were significantly increased, but after treatment for 1, 2, 3, 4, 5, 6, and 7 d, the levels of IgG, IgA, IgM, CD3⁺, CD4⁺, and CD8⁺in the treatment group were significantly increased, and the difference was statistically significant in the same group (P<0.05). And the observational indexes in the treatment group were significantly higher than those in the control group, with significant difference between two groups (P<0.05). Conclusion Huanglian Jiedu Pills combined with ribavirin has clinical curative effect in treatment of pediatric herpetic stomatitis, can improve clinical symptoms, and enhance children's immunity, which has a certain clinical application value.