[关键词]
[摘要]
目的 探讨骨康胶囊联合碳酸钙D3片治疗老年骨质疏松性桡骨远端骨折的临床疗效。方法 选择2012年7月-2015年6月黄石煤炭矿务局职工医院收治的骨质疏松性桡骨远端骨折患者72例,随机分为对照组和治疗组,每组各36例。两组均给予手术切开复位处理,对照组术后口服碳酸钙D3片,1.8 g/次,3次/d。治疗组在对照组基础上口服骨康胶囊,1.2~1.6 g/次,3次/d。两组患者均治疗6个月。比较两组的腕关节功能恢复情况、骨代谢、骨密度、住院时间和骨折愈合时间。结果 治疗后,对照组和治疗组的优良率分别为72.22%、91.67%,两组比较差异有统计学意义(P<0.05)。治疗后,两组TP1NP和BGP均上升,而β-CTX均下降,同组治疗前后比较差异有统计学意义(P<0.05);且治疗组这些观察指标的改善程度明显优于对照组,两组比较差异具有统计学意义(P<0.05)。治疗后,两组腰椎L2-4、股骨颈、Ward三角和大粗隆骨密度均上升,同组治疗前后比较差异有统计学意义(P<0.05);且治疗组这些观察指标的上升程度明显优于对照组,两组比较差异具有统计学意义(P<0.05)。治疗后,治疗组住院时间和骨折愈合时间均短于对照组,两组比较差异具有统计学意义(P<0.05)。结论 骨康胶囊联合碳酸钙D3片可加速老年骨质疏松性桡骨远端骨折患者术后骨折愈合速度,缩短住院时间,促进患者骨形成,抑制骨吸收,调节骨代谢,提高骨密度,具有一定的临床推广应用价值。
[Key word]
[Abstract]
Objective To investigate the clinical effect of Gukang Capsules combined with Calcium Carbonate and Vitamin D3 Tablets in treatment of elderly patients with osteoporotic distal radius fractures. Methods Patients (72 cases) with osteoporotic distal radius fractures in Huangshi Mining Hospital from July 2012 to June 2015 were randomly divided into control and treatment groups, and each group had 36 cases. All patients were given open reduction surgery. Patients in the control group were po administered with Calcium Carbonate and Vitamin D3 Tablets, 1.8 g/time, three times daily. Patients in the treatment group were po administered with Gukang Capsules on the basis of the control group, 1.2-1.6 g/time, three times daily. Patients in two groups were treated for 6 months. After treatment, the clinical efficacies were evaluated, and functional recovery of wrist joint, bone metabolism, bone density, hospitalization time, and fracture healing time in two groups were compared. Results After treatment, the excellent rates in the control and treatment groups were 72.22% and 91.67%, respectively, and there was difference between two groups (P<0.05). After treatment, TP1NP and BGP in two groups in two group were significantly increased, but the β-CTX in two groups were significantly decreased, and the difference was statistically significant in the same group (P<0.05). And the observational indexes in the treatment group were significantly better than those in the control group, with significant difference between two groups (P<0.05). After treatment, the bone density of lumbar L2-4, femoral neck, Ward triangle, greater trochanter in two groups were significantly increased, and the difference was statistically significant in the same group (P<0.05). And the observational indexes in the treatment group were significantly higher than those in the control group, with significant difference between two groups (P<0.05). After treatment, hospitalization time and fracture healing time in the treatment group were shorter than those in the control group, and there was difference between two groups (P<0.05). Conclusion Gukang Capsules combined with Calcium Carbonate and Vitamin D3 Tablets can accelerate postoperative fracture healing of elderly patients with osteoporotic distal radius fractures, shorten hospitalization time, promote bone formation, inhibit bone resorption, regulate bone metabolism, and increase bone density, which has a certain clinical application value.
[中图分类号]
[基金项目]