目的 探讨康复新液联合米诺环素软膏治疗慢性牙周炎的临床疗效。方法 选取2013年8月-2015年8月三亚市人民医院收治的慢性牙周炎患者90例，患牙共计106颗，采用随机数字表法分为对照组和治疗组，每组各45例、患牙53颗。对照组给予盐酸米诺软膏，将其注入牙周袋中直至充满，1次/周；治疗组在对照组基础上给予康复新液，约10 mL含漱5 min左右，4次/d。两组患者均治疗4周。观察两组的临床疗效，比较两组C反应蛋白（CRP）、白细胞介素-6（IL-6）、龈沟出血指数（SBI）、牙周附着水平（AL）、菌斑指数（PLI）和牙周袋深度（PD）变化情况。结果 治疗后，对照组和治疗组的总有效率分别为79.25%、96.23%，两组比较差异有统计学意义（P<0.05）。治疗后，对照组SBI、AL、PLI和PD显著降低，治疗组CRP、SBI、AL、PLI和PD显著降低，同组治疗前后比较差异有统计学意义（P<0.05）；且治疗组这些观察指标的降低程度明显优于对照组，两组比较差异具有统计学意义（P<0.05）。结论 康复新液联合米诺环素软膏治疗慢性牙周炎具有较好的临床疗效，能改善临床症状，缓解炎症反应，具有一定的临床推广应用。

Objective To investigate the clinical effect of Kangfuxin Liquid combined with Minocycline Ointment in treatment of chronic periodontitis. Methods Patients (90 cases, 106 teeth) with chronic periodontitis in Sanya People's Hospital from August 2013 to August 2015 were randomly divided into control and treatment groups by random digits table, and each group had 45 cases and 53 teeth. Patients in the control group were given Minocycline Hydrochloride Ointment, they were injected into the periodontal pocket until full, once weekly. Patients in the treatment group were given Kangfuxin Liquid on the basis of the control group, about 10 mL gargled about 5 min, four times daily. Patients in two groups were treated for 4 weeks. After treatment, the clinical efficacies were evaluated, and CPR, IL-6, SBI, AL, PLI, and PD in two groups were compared. Results After treatment, the clinical efficacies in the control and treatment groups were 79.25% and 96.23%, respectively, and there was difference between two groups (P<0.05). After treatment, SBI, AL, PLI, and PD in the control group were significantly decreased, and CPR, SBI, AL, PLI, and PD in the treatment group were significantly decreased, and the difference was statistically significant in the same group (P<0.05). And the observational indexes in the treatment group were significantly lower than those in the control group, with significant difference between two groups (P<0.05). Conclusion Kangfuxin Liquid combined with Minocycline Ointment has clinical curative effect in treatment of chronic periodontitis, and can improve clinical symptoms, relieve inflammation reactions, which has a certain clinical application value.