目的 观察肾复康胶囊联合百令胶囊治疗慢性肾小球肾炎的疗效。方法 选取2012年1月-2015年12月在天津市第一中心医院肾内科就诊且确诊为慢性肾小球肾炎患者95例,随机分为对照组(48例)和治疗组(47例)。对照组患者在常规治疗同时口服百令胶囊,5粒/次,3次/d。治疗组在对照组的基础上口服肾复康胶囊,4粒/次,3次/d。两组患者均连续治疗12周。观察记录两组患者的临床总有效率、治疗前后24 h尿蛋白定量、尿红细胞计数(RBC)、尿素氮(BUN)、血肌酐(Scr)的水平变化。结果 治疗后,对照组和治疗组总有效率分别为85.42%、93.62%,两组差异比较具有统计学意义(P<0.05);两组患者的24 h尿蛋白、RBC、BUN和Scr水平均显著降低,同组治疗前后差异具有统计学意义(P<0.05);且治疗组患者降低程度更为明显,两组比较差异具有统计学意义(P<0.05)。结论 肾复康胶囊联合百令胶囊治疗慢性肾小球肾炎具有良好的疗效,能够改善肾功能指标,具有一定的临床推广应用价值。

Objective To explore the clinical effect of Kouyanqing Granules combined with triamcinolone acetonide in treatment of oral lichen planus. Methods The clinical data of 78 patients with oral lichen planus in China Medical University Stomatology Hospital from January 2014 to October 2015 were retrospectively analyzed, and were randomly divided into control group (39 cases) and treatment group (39 cases). All patients were given basic treatment to reduce the stimulation to oral mucosa. The patients in the control group were injected with Triamcinolone Acetonide Acetate Injection in lesion mucosal basement, 10 mg dissolved in 2% lidocaine 2.5 mL, once a week. The patients in the treatment group were po administered with Kouyanqing Granules on the basis of the control group, 2 bags/time, twice daily. The patients in two groups were treated for 4 weeks. After treatment, clinical efficacies in two groups were evaluated. And the changes of scores of physical signs, pain and life quality were compared. In the same time, the levels of serum IL-2, IL-4, and TNF-α in two groups before and after treatment were determined. Results After treatment, the total efficacies in the control group and treatment group were 84.62% and 97.44%, respectively, and there were differences between two groups (P < 0.05). After treatment, the scores of physical signs, pain and life quality in two groups were significantly decreased (P < 0.05), and the scores in the treatment group were significantly lower than those in the control group, with significant difference between two groups (P < 0.05). After treatment, the levels of serum IL-2, IL-4, and TNF-α in two groups weresignificantly decreased (P < 0.05), and the reductions in treatment group were more obvious, with significant difference between two groups (P < 0.05). Conclusion Kouyanqing Granules combined with triamcinolone acetonide has a significant curative effect in treatment of oral lichen planus, can significantly decrease the levels of serum inflammatory cytokines, and effectively improve clinical symptoms, which has a certain clinical application value.