目的 研究丁苯酞软胶囊联合注射用尤瑞克林治疗急性脑梗死患者的临床疗效。方法 选取2014年4月-2015年3月天津市环湖医院收治的急性脑梗死患者150例,根据抽取法将所有患者分为对照组和治疗组,每组各75例。对照组静脉滴注注射用尤瑞克林,0.15PNA加入生理盐水250mL中,30min内滴完,1次/d。治疗组在对照组治疗基础上口服丁苯酞软胶囊,0.2g/次,4次/d。两组患者均连续治疗14d。观察两组患者在治疗前后血管内皮功能指标、日常生活能力(ADL)评分和神经功能评分情况,同时比较两组患者的临床疗效和在治疗过程中的不良反应发生率。结果 治疗后,两组患者的血浆内皮素-1水平明显降低,血浆一氧化氮水平显著升高,同组治疗前后比较差异具有统计学意义(P<0.05);且治疗组这些观察指标的改善程度均优于对照组,两组比较差异具有统计学意义(P<0.05)。治疗后,两组患者的ADL评分显著升高,神经功能评分明显降低,同组治疗前后比较差异具有统计学意义(P<0.05);且治疗组这些观察指标的改善程度均优于对照组,两组比较差异具有统计学意义(P<0.05)。治疗后,对照组和治疗组的总有效率分别为74.67%、90.67%,两组比较差异有统计学意义(P<0.05)。治疗组和对照组的不良反应率分别为4.00%、2.67%,组间比较差异不明显。结论 丁苯酞软胶囊联合注射用尤瑞克林治疗急性脑梗死的临床疗效较好,能够明显改善血管内皮功能、日常生活能力和神经功能,不良反应率低,安全性高,具有一定的临床推广应用价值。

Objective To study the effect of Butylphthalide Soft Capsules combined with Urinary Kallidinogenase for injection in treatment of acute cerebral infarction. Methods Patients (150 cases) with acute cerebral infarction in Tianjin Huanhu Hospital from April 2014 to March 2014 were randomly divided into control and treatment groups according to the extraction method, and each group had 75 cases. Patients in the control group were iv administered with Urinary Kallidinogenase for injection, 0.15 PNA added into 250 mL normal saline, finished during 30 min, once daily. The patients in treatment group were po administered with Butylphthalide Soft Capsules on the basis of the control group, 0.2 g/time, four times daily. The patients in two groups were treated for 14 d. After treatment, endothelial function index, ability of daily life (ADL) score, and nerve function score in two groups were observed, and efficacy and the incidence of adverse reactions in two groups during the process of treatment was evaluated. Results After treatment, levels of plasma endothelin-1 in two groups were significantly decreased, but levels of plasma nitric oxide in two groups were obviously increased, and the difference was statistically significant in the same group (P < 0.05). After treatment, the observational indexes in the treatment group were significantly better than those in the control group, with significant difference between two groups (P < 0.05). After treatment, ADL scores in two groups were significantly increased, but nerve function scores in two groups were obviously decreased, and the difference was statistically significant in the same group (P < 0.05). After treatment, the observational indexes in the treatment group were significantly better than those in the control group, with significant differenc between two groups (P < 0.05). After treatment, the efficacies in the control and treatment groups were 74.67% and 90.67%, respectively, and there were differences between two groups (P < 0.05). Adverse reaction rates of the treatment group and the control group were 4.00% and 2.67%, respectively, but there was no difference between two groups. Conclusion Butylphthalide Soft Capsules combined with Urinary Kallidinogenase for injection has clinical curative effect in treatment of acute cerebral infarction, can significantly improve endothelial function, ability of daily life, and nerve function, and has less adverse reactions, which has a certain clinical application value.