目的 观察稳心颗粒联合胺碘酮和贝那普利治疗老年阵发性心房颤动的临床疗效。方法 选取2013年6月-2014年6月淄博化建医院收治的老年阵发性心房颤动患者126例,随机分为对照组和治疗组,每组各63例。对照组患者口服盐酸胺碘酮片,1片/次,3次/d,2周后改为2次/d;同时口服盐酸贝那普利片,1片/次,1次/d。治疗组在对照组治疗基础上口服稳心颗粒,1袋/次,3次/d。两组均连续治疗12个月。观察两组的临床疗效,同时比较两组患者治疗前后左心房内径、左室收缩末期内径(LVSD)、左室内径短轴缩短率(FS)、左室射血分数(EF)、B型纳尿肽(BNP)的变化情况。结果 治疗后,对照组和治疗组的总有效率分别为84.13%、95.24%,两组比较差异有统计学意义(P<0.05)。治疗3、6、12个月时,对照组左心房内径均较治疗前显著升高,治疗12个月时对照组LVSD、BNP显著降低,治疗6、12个月时对照组FS、EF显著升高,同治疗前比较差异有统计学意义(P<0.05);治疗3、6、12个月时,治疗组左心房内径、FS、EF均显著升高,LVSD、BNP显著降低,同治疗前比较差异有统计学意义(P<0.05);治疗组这些观察指标的改善程度优于对照组,两组比较差异有统计学意义(P<0.05)。结论 稳心颗粒联合胺碘酮和贝那普利治疗老年阵发性心房颤动具有较好的临床疗效,可显著抑制左心房扩大,改善患者心功能,具有一定的临床推广应用价值。

Objective To observe the clinical effect of Wenxin Granles combined with amiodarone and benazepril in treatment of elderly paroxysmal atrial fibrillation. Methods Patients (126 cases) with paroxysmal atrial fibrillation in Zibo Sinopec Construction Hospital from June 2013 to June 2014 were randomly divided into control (n=63) and treatment (n=63) groups. The patients in the control group were po administered with Amiodarone Hydrochloride Tablets, 1 tablet/time, three times daily, two weeks later twice daily instead. And they were po administered with Benazepril Hydrochloride Tablets, 1 tablet/time, once daily. The patients in the treatment group were po administered with Wenxin Granles on the basis of the control group, 1 bag/time, three times daily. The patients in two groups were treated for 12 months. After treatment, the efficacy was evaluated, and the changes of left atrium diameter, LVSD, FS, EF, and BNP in two groups before and after treatment were compared. Results After treatment, the efficacies in the control and treatment groups were 84.13% and 95.24%, respectively, and there were differences between two groups (P < 0.05). At treatment of 3, 6, and 12 months, left atrium diameter in control group were significantly increased, while LVSD and BNP in the control group were significantly decreased at treatment of 12 months, FS and EF in the control group were significantly increased at treatment for 6, 12 months, and the difference was statistically significant in the same group (P < 0.05). Left atrium diameter, FS, and EF in the treatment group were significantly increased at treatment for 3, 6, 12 months, LVSD and BNP were significantly decreased, and the difference was statistically significant in the same group (P < 0.05). After treatment, the observational indexes in the treatment group were significantly better than those in the control group, with significant difference between two groups (P < 0.05). Conclusion Wenxin Granles combined with amiodarone and benazepril has clinical curative effect in treatment of elderly paroxysmal atrial fibrillation, and can significantly inhibit the left atrial enlargement, and can improve cardiac function, which has a certain clinical application value.