芪苈强心胶囊是基于络病学气血水同治理论研制而成的中成药,近年来大量研究证据表明其在治疗心力衰竭方面具有很好的疗效。该药物能改善心力衰竭发生发展各阶段的生理病理基础,其作用机制包括抑制神经内分泌的过度激活、保护血管内皮、阻断离子通道、抑制心室重构和代谢重构等。综述了芪苈强心胶囊上述各方面药理作用的研究进展,以期为芪苈强心胶囊的临床合理使用提供理论依据和临床证据。

Qiliqiangxin Capsules, a Chinese patent drug, is developed based on collateral disease theory of blood-water co-treatment. Recently, many research evidences have shown an obvious effect of Qiliqiangxin Capsules on heart failure. The drug can improve physiological and pathological basis of heart failure with mechanisms including prevention of excessive activation of neuroendocrine, protection of vascular endothelium, blockage of ion channel, and inhibition of ventricular and metabolic remodeling. This paper overviewed the research progress on above-mentioned effects of Qiliqiangxin Capsules in order to provide theoretical and clinical support for its reasonable application in clinic.

国家中医药管理局"十二五"中医心血管科重点专科项目;天津市中医药管理局中医、中西医结合科研专项课题(2015050)