目的 研究灯盏细辛注射液联合胞磷胆碱钠胶囊治疗脑梗死患者的临床疗效。方法 2012年1月—2015年2月北京市东城区第一人民医院神经内科收治的脑梗死患者84例,随机分为对照组和治疗组,每组各42例。对照组在常规治疗的基础上口服胞磷胆碱钠胶囊,0.2 g/次,3次/d。治疗组在对照组治疗基础上静脉滴注灯盏细辛注射液,40 mL加入0.9%生理盐水250 mL中,1次/d。两组患者的治疗时间均为14 d。观察两组的临床疗效,同时比较两组治疗前后超氧化物岐化酶(SOD)、血清超敏C反应蛋白(CRP)、神经功能缺损程度(NIHSS)评分、Barthel指数、血浆黏度、全血黏度、纤维蛋白原、血小板聚集率、红细胞压积的变化情况。结果 治疗后,对照组和治疗组的总有效率分别为61.90%、83.33%,两组比较差异有统计学意义(P<0.05)。治疗后,两组患者CRP、NIHSS评分、血浆黏度、全血黏度、纤维蛋白原、血小板聚集率、红细胞压积均显著降低,SOD、Barthel指数均显著升高,同组治疗前后差异具有统计学意义(P<0.05);且治疗组这些观察指标的改善程度优于对照组,两组比较差异具有统计学意义(P<0.05)。结论 灯盏细辛注射液联合胞磷胆碱钠胶囊治疗脑梗死具有较好的临床疗效,有利于患者神经功能的恢复,改善生活能力,具有较好的临床使用价值。

Objective To study the effect of Dengzhanxixin Injection combined with Citicoline Sodium Capsules in treatment of cerebral infarction. Methods Patients (84 cases) with cerebral infarction in Department of Neurology of the First People's Hospital of Beijing Dongcheng District from 2013 January to 2015 February were randomly divided into control and treatment groups, and each group had 42 cases. The patients in the control group were po administered with Citicoline Sodium Capsules on the basis of conventional treatment, 0.2 g/time, three times daily. The patients in the treatment group were iv administered with Dengzhanxixin Injection on the basis of control group, 40 mL added into 0.9% normal saline 250 mL, once daily. The patients in two groups were treated for 14 d. After treatment, the clinical efficacy were evaluated, and the changes of SOD, CRP, NIHSS score, Barthel index, whole blood viscosity, plasma viscosity, fibrinogen, platelet aggregation rate and erythrocyte deposited in two groups were compared. Results After treatment, the clinical efficacies in the control and treatment groups were 61.90% and 83.33%, respectively, and there were differences between two groups (P < 0.05). After treatment, CRP, NIHSS score, whole blood viscosity, plasma viscosity, fibrinogen, platelet aggregation rate and erythrocyte deposited were significantly decreased, and SOD and Barthel index were significantly increased, and the difference was statistically significant in the same group (P < 0.05). After treatment, the observational indexes in the treatment group were significantly better than those in the control group, with significant difference between two groups (P < 0.05). Conclusion Dengzhanxixin Injection combined with Citicoline Sodium Capsules has clinical curative effect in treatment of cerebral infarction, benefit to the recovery of neural function, also can improve the living ability of patients, which has a certain clinical application value.