姜黄素类化合物具有明确而广泛的药理作用,但因其溶解度差、结构不稳定,生物利用度极低。主要通过对姜黄素类化合物体内代谢途径及其相关代谢产物进行综述,以明确姜黄素生物利用度低的原因,并提出姜黄素发挥药理活性的物质基础可能与其通过自身氧化和催化氧化过程产生的双环乙酰丙酮结构有关。因此对姜黄素代谢产物进行药动学及相关药效研究,能够为临床应用提供更为关键的基础性数据,也具有更为重要的研究价值。

Curcuminoids have clear and extensive pharmacological effects. However, curcumin has very low bioavailability because of its poor solubility and unstable structure. The metabolic pathways in vivo and their metabolites of curcuminoids are mainly reviewed in this paper, in order to make clear the reason of low bioavailability. Besides, it is inferred that the structure of bicyclopentadiones by autoxidation and catalytic oxygenation plays an important role of the material basis for the pharmacological activities of curcumin. Therefore, the pharmacokinetics and pharmacodynamics research of curcumin metabolites can provide more key foundational data for clinical application, and has more important research value.

国家自然科学基金重点项目(81430096);重大新药创制科技重大专项(2012ZX09303010)