目的 分析2012—2014年天津市肿瘤医院镇痛药物的使用情况,为临床合理使用镇痛药物提供依据。方法 调取2012—2014年天津市肿瘤医院镇痛药物的相关信息,对药物剂型、销售金额、用药频度(DDDs)、日均费用(DDC)及药品排序比(B/A)进行统计分析。结果 2012—2014年镇痛药物的销售金额逐年增加,速释口服剂型及缓、控释制剂构成比远超注射剂,达到97%以上。各品种镇痛药物的DDDs变化较大但排序基本稳定,盐酸布桂嗪注射液、氨酚羟考酮片及芬太尼透皮贴剂的DDDs值分别位居各剂型的首位。大部分镇痛药物的DDC值各年份略有差异,15种药品的DDC值小于100,患者负担较轻。75%镇痛药物的B/A值接近于1,表明用药同步性较好。结论 天津市肿瘤医院镇痛药品的使用日趋合理,但也存在个别药品日均费用较高、同步性较差的问题,需进一步加强管理。

Objective To analyze the utilization of analgesic drugs in Tianjin Cancer Hospital from 2012 to 2014, and to provide reference for rational use of drugs in clinic. Methods The utilization information of analgesic drugs in Tianjin Cancer Hospital from 2012 to 2014 was extracted, and the dosage form of drugs, consumption sum, defined daily doses (DDDs), defined daily cost (DDC) and drug sequence ratio (B/A) were analyzed statistically. Results From 2012 to 2014, the consumption sum of analgesic drugs was increasing year by year, and the constituent ratios of fast-release tablets and sustained release preparation were above 97% far exceeding that of the injection. DDDs of analgesic drugs changed obviously, but the sequences were stable. DDDs of Bucinnazine Hydrochloride Injection, Oxycodone-acetaminophen Tablets and Fentanyl Transdermal System ranked the first in three dosage forms, respectively. DDC of most analgesic drugs had subtle difference, and DDC of 15 drugs were less than 100, which resulted minor economic burden for cancer patient. B/A of 75% analgesic drugs closed to 1.00, indicating that the synchronism was better. Conclusion The utilization of analgesic drugs in Tianjin Cancer Hospital is gradually reasonable. However, the problem of high average daily cost and poor synchronism of few drugs are still existed, which needs further efforts to strengthen the management.