目的 观察益母草注射液联合缩宫素注射液和米索前列醇片治疗子宫收缩乏力性产后出血的治疗效果。方法 选取2014年1月—2015年1月衡水市第二人民医院收治的子宫收缩乏力性产后出血患者66例,随机分为对照组和治疗组,每组各33例。对照组患者午饭后和晚饭后30 min im缩宫素注射液20 U,然后口服米索前列醇片0.6 mg。治疗组患者在对照组基础上于午饭后和晚饭后im益母草注射液2 mL。每个疗程为3 d,两组均连续用药3个疗程。观察两组的临床疗效,记录两组产时、产后2 h以及用药3 d后的出血量,比较两组出血率、平均出血量、不良反应率。结果 治疗后,对照组和治疗组患者总有效率分别为75.8%、90.9%,两组总有效率比较差异具有统计学意义(P<0.05)。两组患者在用药3 d后的出血量比较差异具有统计学意义(P<0.05)。治疗后,治疗组出血率、平均出血量、不良反应率均显著低于对照组,两组比较差异均具有统计学意义(P<0.05)。结论 益母草注射液联合缩宫素注射液和米索前列醇片治疗子宫收缩乏力性产后出血具有较好的临床疗效,可有效减少出血量,降低出血率、平均出血量以及不良反应率,具有一定的临床推广应用价值。

Objective To observe the clinical effect of Yimucao Injection combined with Oxytocin Injection and Misoprostol Tablets in treatment of postpartum hemorrhage caused by uterine inertia. Methods Patients (66 cases) with postpartum hemorrhage caused by uterine inertia in the Second People's Hospital of Hengshui from January 2014 to January 2015 were randomly divided into control and treatment groups, and each group had 33 cases. The patients in the control group were im administered with Oxytocin Injection 20 U 30 min after lunch and dinner, then po administered with Misoprostol Tablets 0.6 mg. The patients in the treatment group were im administered with Yimucao Injection 2 mL on the basis of the control group after lunch and dinner. A course was 3 d, and the patients in two groups were treated for three courses. After treatment, the efficacy was evaluated, blood losses at production, postpartum 2 h, and treated for 3 d were recorded, and bleeding rats, average amounts of bleeding, and adverse reaction rates were compared. Results After treatment, the efficacies in the control and treatment groups were 75.8% and 90.9%, respectively, and there were differences between two groups (P < 0.05). There were differences of blood loss treated for 3 d between two groups (P < 0.05). After treatment, bleeding rats, average amounts of bleeding, and adverse reaction rates were significantly decreased, with significant difference between two groups (P < 0.05). Conclusion Yimucao Injection combined with Oxytocin Injection and Misoprostol Tablets has clinical curative effect in treatment of postpartum hemorrhage caused by uterine inertia, can effective reduce blood loss, decrease bleeding rats, average amounts of bleeding, and adverse reaction rate, which has a certain clinical application value.