目的 比较干预前后江苏省人民医院消化内镜预防用抗菌药物的使用情况,为合理使用抗菌药物提供依据。方法 采集2013年3-9月、2014年3-9月江苏省人民医院消化内科住院患者应用抗菌药物的数据,比较干预前后抗菌药物的使用强度(AUD)、用药选择、给药时机、用药疗程。结果 干预后,各类手术患者抗菌药物的AUD都呈下降趋势。各类抗菌药物的AUD均有所下降,且第3代头孢菌素类的AUD显著降低。第1、2代头孢菌素类抗菌药物的使用例数呈明显上升趋势。各类手术术前预防应用抗菌药物的比例均有所上升。各类手术患者抗菌药物的用药疗程均有所缩短。结论 通过规范消化内镜抗菌药物预防使用,有效加强了消化内科对抗菌药物的临床应用管理,提高了消化内科抗菌药物使用的合理应用水平。

Objective To compare the prophylactic application of antibiotics in digestive endoscopy in Jiangsu Province Hospital before and after intervention, and to provide valuable reference for rational use of antibiotics. Methods The data of prophylactic application of antibiotics in Department of Gastroenterology in Jiangsu Province Hospital in from March to September 2013, and from March to September 2014 were selected, and the antibacterial use density (AUD), selection of medicine, time of administration, and course of treatment were compared before and after intervention. Results After intervention, the AUD of inpatients with different kinds of operation were declined significantly. The AUD of all kinds of antibiotics were declined, and that of the third generation of cephalosporin was declined significantly. The use of the first and second generation of cephalosporin showed a trend of increasing obviously. Furthermore, the rational rates of preoperative prophylactic application of antibiotics were elevated. The courses of prophylactic application of antibiotics were shortened. Conclusion Through standardizing antibiotic prophylaxis of digestive endoscope, it can not only strengthen the management of clinical application of antibacterial drugs effectively, but also improve the rational use of anti-bacteria in Department of Gastroenterology.