目的 观察元胡止痛片联合布洛芬缓释胶囊和维生素B₁片治疗带状疱疹后遗神经痛的临床疗效。方法 选取上海交通大学医学院附属第三人民医院2013年6月-2015年3月收治的带状疱疹后遗神经痛患者98例,随机分为对照组和治疗组,每组各49例。对照组给予布洛芬缓释胶囊0.3 g/次,2次/d,维生素B₁片10 mg/次,3次/d;治疗组在对照组的基础加用元胡止痛片5片/次,3次/d。两组均连续治疗4周。采用VAS法记录治疗前、治疗后24 h、1周、1个月时的VAS评分,对两组患者治疗前后的疼痛程度进行评估;记录两组患者止痛即刻起效时间、疼痛开始缓解时间;观察两组的临床疗效。结果 两组治疗后1周、1个月VAS评分均显著低于同组治疗前(P < 0.05)。治疗组在治疗后24 h、1周、1个月VAS评分均显著低于对照组对应的各时间点,其中治疗组治疗后1周、1个月VAS评分与对照组比较,差异均具有统计学意义(P < 0.05)。治疗后,治疗组止痛即刻起效时间短于对照组,但组间比较差异无显著性,两组疼痛开始缓解时间比较差异具有显著性(P < 0.05),治疗组优于对照组(P < 0.05)。治疗后,对照组和治疗组的总有效率分别为89.80%、97.96%,两组总有效率比较差异有统计学意义(P < 0.05)。结论 元胡止痛片联合布洛芬缓释胶囊和维生素B₁片治疗带状疱疹后遗神经痛具有较好的临床疗效,且安全可靠,具有一定的临床推广应用价值。

Objective To investigate the clinical effect of Yuanhu Zhitong Tablets combined with Bloven Sustained Release Capsules and Vitamin B1 Tablets in treatment of postherpetic neuralgia. Methods Patients (98 cases) with postherpetic neuralgia in Shanghai 3rd People's Hospital, School of Medicine, Shanghai Jiao Tong University, from June 2013 to March 2015 were randomly divided into control and treatment groups, and each group had 49 cases. The patients in the control group were po administered with Bloven Sustained Release Capsules, 0.3 g/time, twice daily, and Vitamin B1 Tablets, 10 mg/time, three times daily. The patients in the treatment group were po administered with Yuanhu Zhitong Tablets on the basis of control group, 5 tablets/time, three times daily. The patients in two groups were treated for 4 weeks. VAS scores were recorded before treatment, and 24 h, 1 week, and 1 month after the first treatment by VAS method to evaluate the degree of pains. The time for inducing pain remssion and the pain relief time were recorded. After treatment, the efficacy was evaluated. Results After treatment at time point of 1 week and 1 month after the first treatment, VAS scores were significantly reduced in both groups compared than those in the same group before treatment (P < 0.05). VAS scores in the treatment group were significantly lower than those in control group at time point of 24 h, 1 week, and 1 month after the first treatment, and there was difference between two groups t time point of 1 week and 1 month after the first treatment (P < 0.05). There was no significant difference in the time for inducing pain remssion between the two groups after treatment, but the time for pain relief time of treatment group was better than that in the control group, the difference was statistically significant (P < 0.05). After treatment, the efficacies in the control and treatment groups were 89.80% and 97.96%, respectively, and there were significant differences between two groups (P < 0.05). Conclusion Yuanhu Zhitong Tablets combined with Bloven Sustained Release Capsules and Vitamin B1 Tablets has good clinical effect in treatment of in treatment of postherpetic neuralgia with no serious adverse reaction, which has a certain clinical value.