目的 研究消癌平注射液联合顺铂治疗膀胱癌的临床疗效。方法 选取2011年5月到2014年12月来北京中医药大学东方医院就诊的膀胱癌患者100例,随机分为对照组和治疗组,每组50例。对照组注入注射用顺铂60 mg加40 mL生理盐水进行局部灌注,每周治疗3次,3周为1个周期。治疗组在对照组的基础上给予消癌平注射液,每次2支,1次/d,3周为1个周期。两组患者均治疗3个周期。比较两组患者治疗后近期疗效、近期生活质量评分以及药物的不良反应发生情况。结果 治疗组患者治疗后的有效率为90.0%,高于对照组72.0%,差异具有统计学意义(P < 0.05)。治疗后治疗组患者自觉症状、日常生活、社会活动、心理情绪状态、躯体生理功能状态和总得分均高于对照组,差异有统计学意义(P < 0.05)。治疗组患者白细胞降低、血小板减少、恶心呕吐、脱发、贫血、皮疹等不良反应发生率均小于对照组,差异具有统计学意义(P < 0.05)。结论 消癌平注射液联合注射用顺铂治疗膀胱癌的有效率较高,可明显改善患者的生活质量,不良反应少,效果满意,值得在临床上进一步推广和应用。

Objective To explore the clinical effects of Xiaoaiping Injection combined with cisplatin in the treatment of bladder cancer. Methods Patients (100 cases) with bladder cancer of Dongfang Hospital of Beijing University of Chinese Medicine from May 2011 to December 2014 were randomly divided into control and treatment groups, and each group had 50 cases. The patients in the control group were iv administered with Cisplatin for injection 6 mg added in 40 mL normal saline, three times per week, and 3 weeks undergoing therapy as one treatment period. The patients in the treatment group were iv administered with Xiaoaiping Injecton on the basis of control group, 2 tubes/time, once daily. One course of treatment was three weeks, and two groups were treated for three courses. After treatment, the efficacy was evaluated, and recent quality of life and drug adverse reactions of two groups were observed. Results After treatment, the total effective rate of treatment groups was 90.0%, which was higher than that (72.0%) of control group, and there were differences between two groups (P < 0.05). The scores of self perceived symptoms, daily life, social activities, psychological and emotional state, physical and physiological function, and total score in the treatment group were significantly higher than those in the control group, with significant difference between two groups (P < 0.05). The incidences of adverse reaction such as white blood cells and platelets reduced, nausea and vomiting, alopecia, anemia, and skin rash were significantly lower than those in the control group, and the difference was statistically significant in the same group (P < 0.05). Conclusion Xiaoaiping Injection combined with Cisplatin for injection in treatment of bladder cancer has higher efficiency, can significantly improve the quality of life of patients, less drug adverse reactions, satisfactory results, which has a certain clinical application value.

北京中医药大学中西医结合肿瘤治疗协同创新中心项目(京中字[2013]198号)