目的 观察疏血通注射液联合肾康注射液治疗急性肾损伤的临床疗效。方法 选取2013年1月-2015年1月徐州医学院附属淮安医院收治的急性肾损伤患者112例,随机分为对照组和治疗组,每组各56例。对照组在基础治疗上静脉滴注肾康注射液,100 mL/次加入5%葡萄糖注射液300 mL中,1次/d。治疗组在对照组的基础上静脉滴注疏血通注射液,6 mL/次加入5%葡萄糖注射液250 mL,1次/d。两组均连续治疗21 d。观察两组的临床疗效,同时比较血肌酐(Scr)、内生肌酐清除率(CCR)、尿β₂-微球蛋白(β₂-MG)、尿渗透压、尿素氮(BUN)、24 h尿蛋白(Upro)、血清芳香酯酶(ArE)、总胆固醇(TC)、高密度脂蛋白胆固醇(HDL-C)、载脂蛋白A(Apo-A)、载脂蛋白B(Apo-B)、急性生理学与慢性健康状况(A-PACHEⅡ)评分的变化。结果 治疗后,对照组和治疗组的总有效率分别为71.43%、87.50%,两组比较差异有统计学意义(P < 0.05)。治疗7、14、21 d两组Scr均呈下降趋势,CCR呈上升趋势,同组治疗前后差异具有统计学意义(P < 0.05);且治疗组Scr、CCR的改善程度优于同期对照组水平,两组比较差异具有统计学意义(P < 0.05)。治疗后,两组患者β₂-MG、Scr、BUN、Upro、TC、Apo-B、A-PACHEⅡ评分均显著降低,尿渗透压、ArE、HDL-C、Apo-A均显著升高,同组治疗前后差异具有统计学意义(P < 0.05);且治疗组这些观察指标的改善程度优于对照组,两组比较差异具有统计学意义(P < 0.05)。结论 疏血通注射液联合肾康注射液治疗急性肾损伤疗效确切,可显著改善患者肾功能及血脂指标,具有一定的临床推广应用价值。

Objective To observe the clinical efficacy of Shuxuetong Injection combined with Shenkang Injection in treatment of acute kidney injury. Methods Patients (112 cases) with acute kidney injury in Huai'an Hospital Affiliated to Xuzhou Medical College from January 2013 to January 2015 were randomly divided into control and treatment groups, and each group had 56 cases. The patients in control group were iv administered with Shenkang Injection, 100 mL/time Shenkang Injection added into 5% glucose injection 300 mL, once daily. The patients in treatment group were iv administered with Shuxuetong Injection on the basis of control group, 6 mL/time Shenkang Injection added into 5% glucose injection 250 mL, once daily. Two groups were treated for 21 d. After treatment, the efficacy was evaluated, and the changes of Scr, CCR, β₂-MG, urine osmotic pressure, BUN, Upro, ArE, TC, HDL-C, Apo-A, Apo-B, A-PACHEⅡ scores in two groups before and after treatment were compared. Results After treatment, the efficacies in control and treatment groups were 71.43% and 87.50%, respectively, and there were differences between two groups (P < 0.05). After treatment of 7, 14, and 21 d, Scr levels in two groups presented a downward trend, CCR presented a rising trend, and the difference was statistically significant in the same group (P < 0.05). After treatment, β₂-MG, Scr, BUN, Upro, TC, Apo-B, and A-PACHEⅡ scores in two groups were significantly decreased, and urine osmotic pressure, ArE, HDL-C, and Apo-A were increased, and the difference was statistically significant in the same group (P < 0.05). The improvement degrees of observational indexes were better than those in the control group, with significant difference between two groups (P < 0.05). Conclusion Shuxuetong Injection combined with Shenkang Injection has curative effect in treatment of acute kidney injury, and can significantly improve the kidney function and blood lipids index, which has a certain clinical application value.