目的 探讨复方血栓通胶囊联合氯沙坦治疗高血压的临床疗效。方法 选择2013年6月-2015年5月延安市人民医院收治的原发性高血压患者80例,随机分为对照组和治疗组,每组各40例。对照组给予常规药物对症治疗,并于早晨口服氯沙坦钾片,50 mg/次,1次/d。治疗组患者在对照组基础上加服复方血栓通胶囊,3粒/次,3次/d。1个月为1个疗程,两组均连续治疗2个疗程。观察两组的临床疗效,比较两组患者头痛、眩晕的改善情况。同时比较两组患者治疗前后收缩压(SBP)、舒张压(DBP)、左心室舒张末期内径(LVDd)、左心室舒张末期室间隔厚度(IVST)、左心室舒张末期后壁厚度(LVPWT)的变化情况。结果 治疗后,对照组和治疗组的总有效率分别为75.0%、92.5%,两组比较差异具有统计学意义(P < 0.05)。两组头痛、眩晕的总有效率分别为67.5%、87.5%,72.5%、90.0%,两组比较差异具有统计学意义(P < 0.05)。治疗后,两组SBP、DBP、LVDd、IVST、LVPWT均较治疗前显著降低,同组治疗前后差异具有统计学意义(P < 0.05);治疗后,治疗组这些观察指标的改善程度优于对照组,两组比较差异具有统计学意义(P < 0.05)。结论 复方血栓通胶囊联合氯沙坦治疗原发性高血压临床疗效显著,可控制患者血压水平及改善左心室肥大情况,具有一定的临床应用价值。

Objective To investigate the clinical efficacy of Compound Xueshuantong Capsule combined with losartan in treatment of hypertension. Methods Patients (80 cases) with hypertension in Yan'an People's Hospital from June 2013 to May 2015 were randomly divided into control and treatment groups, and each group had 40 cases. The patients in the control group were given conventional symptomatic treatment drugs, and they were po administered with Losartan Potassium Tablets in the morning, 50 mg/time, once daily. The patients in the treatment group were po administered with Compound Xueshuantong Capsules on the basis of the control group, 3 grains/time, three times daily. A month was as one course of treatment, and two groups were treated for two courses. After treatment, the efficacy was evaluated, and the improve situation of headache and dizziness in two groups were compared. The changes of systolic blood pressure (SBP), diastolic blood pressure (DBP), left ventricular end-diastolic diameter (LVDd), left ventricular end-diastolic ventricular septal thickness (IVST), and left ventricular end-diastolic wall thickness (LVPWT) in two groups were compared. Results After treatment, the efficacies in the control and treatment groups were 75.0% and 92.5%, respectively, and there were differences between two groups (P < 0.05). The efficacies of headache and dizziness in the control and treatment groups were 67.5% and 87.5%, 72.5% and 90.0%, respectively, and there was difference between two groups (P < 0.05). After treatment, SBP, DBP, LVDd, IVST, and LVPWT in two groups were significantly decreased, and the difference was statistically significant in the same group (P < 0.05). The improved degree of those observation indicators in the treatment group was better than those in the control group, with significant difference between two groups (P < 0.05). Conclusion Compound Xueshuantong Capsule combined with losartan has distinct clinical effect in treatment of hypertension, and can control blood pressure and improve left ventricular hypertrophy, which has certain clinical application value.