目的 观察疏风解毒胶囊治疗小儿上呼吸道感染的临床疗效。方法 选取2013年1月至2014年10月上海中医药大学附属龙华医院收治的上呼吸道感染患儿243例,随机分为对照组和治疗组,其中对照组118例,治疗组125例。两组患儿均予休息、口服补液、止咳等对症支持治疗,治疗组同时给予疏风解毒胶囊,4～6岁,2粒/次;6～10岁,3粒/次;10～13岁,4粒/次。3次/d,口服或温水冲服,疗程7 d。疗程内达临床治愈患儿予以停药。记录并比较患儿第1、3、7天白细胞或中性粒细胞异常、肺部啰音、胸部X线异常以及体温正常、咳嗽恢复、咽部红肿改善情况。同时观察两组的临床疗效和不良反应。结果 治疗第3天,两组白细胞或中性粒细胞异常患儿例数比较差异具有统计学意义(P< 0.05);治疗第3、7天,两组肺部啰音、胸部X线异常的患儿例数差异比较具有统计学意义(P< 0.05)。与对照组比较,治疗后第1天,治疗组患儿体温正常、咳嗽恢复情况好于对照组,差异均具有统计学意义(P< 0.05);治疗后第3、7天,治疗组患儿体温正常、咳嗽恢复、咽部红肿改善情况好于对照组,差异具有统计学意义(P< 0.05)。治疗后,治疗组总有效率为92.80%,明显高于对照组的总有效率81.35%,两组总有效率比较差异具有统计学意义(P< 0.05)。两组均未出现明显的不良反应。结论 疏风解毒胶囊在常规治疗基础上治疗小儿急性上呼吸道感染具有较好的临床疗效,无明显不良反应,具有一定的临床推广价值。

Objective To observe the clinical curative effect of Shufeng Jiedu Capsules in treatment of pediatric acute upper respiratory tract infection. Methods Children (243 cases) with acute upper respiratory tract infection in Longhua Hospital Shanghai University of Traditional Chinese Medicine from January 2013 to October 2014 were randomly divided into control group (118 cases) and treatment group (125 cases). Children in two groups were treated with conventional treatment, such as rest, supplement of fluid, relief of cough, etc. Children in the treatment group were po administered with Shufeng Jiedu Capsules on the basis of conventional treatment, 4-6 years old, 2 grain/time; 6-10 years old, 3 grain/time; 10-13 years old, 4 grain/time; three times daily, po or taken with warm water. Two groups were treated for 7 d, but drugs would be stopped within course when clinical curative effects were obtained. Leukocyte or neutrophil abnormalities, rales, abnormal chest X-ray, normal temperature, cough recovery, and throat swelling improvement were recorded and compared on days 1, 3, and 7. At the same time, the efficacy was evaluated, and adverse reactions were observed. Results On day 3 of treatment, there were differences in cases of leukocyte or neutrophil abnormalities between two groups (P < 0.05). And on days 3 and 7 of treatment, there were differences in cases of rales and abnormal chest X-ray between two groups (P < 0.05). Compared with control group, on day 1 of treatment, condition of normal temperature and cough recovery in treatment group were better than those in control group, with significant differences between two groups (P < 0.05). While on days 3 and 7 of treatment, condition of normal temperature, cough recovery, and throat swelling improvement in treatment group were better than those in control group, with significant differences between two groups (P < 0.05). After treatment, the efficacies in the control and treatment groups were 81.35% and 92.80%, respectively, and there was difference between two groups (P < 0.05). There were no adverse events between two groups. Conclusion Shufeng Jiedu Capsules on the basis of conventional treatment can improve the curative effect of pediatric acute upper respiratory tract infection with no serious adverse reaction, which has a certain clinical value.