目的 探讨3种微生态制剂治疗婴儿腹泻的临床疗效。方法 选择2013 年5 月—2015 年1 月天津市第一医院收治的非感染性腹泻患儿120 例,随机分为布拉氏酵母菌组、酪酸梭肠球菌组和枯草杆菌组,每组各40 例。布拉氏酵母菌组患儿口服布拉氏酵母菌散,<1 个月,0.125 g/次,2 次/d;≥1 个月,0.25 g/次,1 次/d。酪酸梭肠球菌组口服酪酸梭肠球菌三联活菌片,<1 个月,0.05 g/次,3次/d;≥1 个月,0.07 g/次,3次/d。枯草杆菌组口服枯草杆菌二联活菌颗粒,<1 个月,0.5 g/次,2 次/d;≥1 个月,1.0 g/次,2 次/d。3 组患儿均连续治疗5 d。观察3 组患儿的临床疗效、腹泻次数、腹泻好转时间及脱水情况。结果 布拉氏酵母菌组、酪酸梭肠球菌组和枯草杆菌组的总有效率分别为95.0%、75.0%、72.5%,布拉氏酵母菌组的总有效率显著高于其他两组,差异具有统计学意义(P <0.05)。治疗后,布拉氏酵母菌组的腹泻次数及腹泻好转时间明显短于其他两组,且布拉氏酵母菌的脱水情况轻于其他两组,差异具有统计学意义(P <0.05)。结论 布拉氏酵母菌治疗婴儿非感染性腹泻临床效果较好,可缩短患儿的腹泻病程,值得临床推广应用。

Objective To explore the clinical curative effect of three kinds of probiotics in treatment of infantile noninfectious diarrhea.Methods Patients (120 cases) with noninfectious diarrhea in the First Hospital of Tianjin from May 2013 to January 2015 were randomly divided into saccharomyces boulardii, clostridium butyricum, and bacillus subtilis groups, and each group had 40 cases. The patients in saccharomyces boulardii group were po administered with Saccharomyces Boulardii Sachets,<1 month 0.125 g/time, twice daily;≥1 month 2.5 g/time, once daily. The patients in clostridium butyricum group were po administered with Laosuan Spindle Enterococcus Triple Viable Tablets,<1 month 0.05 g/time, three times daily;≥1 month 0.07 g/time, three times daily. The patients in bacillus subtilis group were po administered with Combined Bacillus Subtilis and Enterococcus Faecium Granules with Multivitamines,<1 month 0.5 g/time,twice daily;≥1 month 1.0 g/time, twice daily. Two groups were treated for 5 d. After treatment, the efficacy, diarrhea frequency, diarrhea turnaround time, and dehydrated situation in three groups were observed. Results After treatment, efficacies in saccharomyces boulardii,clostridium butyricum, and bacillus subtilis groups were 95.0%, 75.0%, and 72.5%, and the efficacies in saccharomyces boulardii group was obviously higher than those in the other two groups, and the difference was statistically significant (P<0.05). After treatment, diarrhea frequency and diarrhea turnaround time in saccharomyces boulardii group was obviously shorter than those in the other two groups, and dehydration in saccharomyces boulardii group was lighter than that in the other two groups, and the difference was statistically significant(P<0.05). Conclusion Saccharomyces boulardii has good clinical effect in treatment of infantile noninfectious diarrhea, and can shorten the diarrhea duration, which is worthy of clinical popularization and application.