目的 研究雷公藤多苷联合泼尼松治疗亚急性甲状腺炎的临床疗效。方法 选取2013年12月—2014年8月日照市妇幼保健院内科收治的亚急性甲状腺炎患者104例,随机分为对照组和治疗组,每组各52例。对照组患者口服醋酸泼尼松片30 mg/d,应用1周以后进行减量,每周降低5 mg,最后维持5 mg/d。治疗组在对照组治疗的基础上口服雷公藤多苷片2片/次,3次/d。两组均连续治疗2个月。观察两组的临床疗效,同时比较两组退热时间、甲状腺缩小时间、血沉恢复时间及复发率。结果 治疗后,对照组和治疗组的总有效率分别为78.85%、92.31%,两组比较差异有统计学意义(P <0.05)。治疗组退热时间、甲状腺缩小时间以及血沉恢复时间均显著短于对照组,两组比较差异具有统计学意义(P <0.05)。随访6个月期间,对照组和治疗组的复发率分别为17.31%、3.85%,两组复发率比较差异具有统计学意义(P <0.05)。结论 雷公藤多苷联合泼尼松治疗亚急性甲状腺炎具有较好的临床疗效,可显著改善患者的临床症状,降低复发率,且无显著不良反应,具有一定的临床推广应用价值。

Objective To observe the clinical curative effect of tripterygium glycosides combined with prednisone in treatment of subacute thyroiditis. Methods Patients (104 cases) with subacute thyroiditis in Maternal and Child Health Care of Rizhao City from December 2013 to August 2014 were randomly divided into control and treatment groups, and each group had 52 cases. The patients in the control group were po administered with Prednisone Acetate Tablets 30 mg/d, the dosage was reduced 5 mg weekly after one week, and finally the dosage was maintained 5 mg/d. The patients in the treatment group were po administered with Tripterygium Glycosides Tablets, 2 tablets/time, three times daily. Two groups were treated for eight weeks. After treatment, the efficacy was evaluated, and the defervescence time, time of thyroid gland to reduce, blood sedimentation recovery time and recurrence rate in two groups were compared. Results After treatment, the efficacies in the control and treatment groups were 78.85% and 92.31%, respectively, and there was difference between two groups (P < 0.05). After treatment, the defervescence time, time of thyroid gland to reduce, and blood sedimentation recovery time in treatment group were shorter than those in the control group, with significant differences between two groups (P < 0.05). During the follow-up of six months, recurrence rate in control and treatment groups were 17.31% and 3.85%, respectively, and there was difference between two groups (P < 0.05). Conclusions Tripterygium glycosides combined with prednisone has good clinical curative effect in treatment of subacute thyroiditis, and can significantly improve the clinical symptoms with no significant adverse reactions, and also can reduce the recurrence rate, which has a certain clinical application value.