目的 探究阿托伐他汀联合坎地沙坦酯治疗原发性高血压的临床疗效。方法 选取2012年1月—2014年11月义马煤业集团股份有限公司收治的原发性高血压患者300例,随机分为对照组和治疗组,每组150例。对照组口服坎地沙坦酯片,2片/次,1次/d。治疗组口服阿托伐他汀钙片1片/次,1次/d,坎地沙坦酯片的用法用量同对照组。两组患者均连续治疗10周。观察两组的临床疗效,同时比较治疗前后两组患者收缩压、舒张压、超敏C反应蛋白(hs-CPR)、内皮素(ET)、一氧化氮(NO)的变化。结果 治疗后,两组总有效率分别为76.67%、90.67%,两组比较差异有统计学意义(P <0.05)。治疗后,两组患者收缩压、舒张压、hs-CRP、ET均较治疗前显著降低,NO显著升高,同组治疗前后比较差异有统计学意义(P <0.05);且治疗组这些观察指标的改善程度优于对照组,两组比较差异有统计学意义(P <0.05)。结论 阿托伐他汀联合坎地沙坦酯治疗原发性高血压具有较好的临床疗效,可改善患者的血管内皮功能和炎症反应,值得在临床上进一步推广和应用。

Objective To explore the clinical effects of atorvastatin combined with candesartan cilexetil in treatment of primary hypertension. Methods Patients (300 cases) with primary hypertension in the General Hospital of Yima Mineral Co. Ltd. Group from January 2012 to November 2014 were randomly divided into control and treatment groups. Each group had 150 cases. Patients in control group were po administered with Candesartan Cilexetil Tablets, 2 tablets/time, once daily. Patients in treatment group were po administered with Atorvastatin Calcium Tablets, 1 tablet/time, once daily, and the usage and dosage of Candesartan Cilexetil Tablets were the same with the control group. Two groups were treated for 10 weeks. After treatment, the efficacy was evaluated, and the changes of systolic and diastolic blood pressure, hs-CPR, ET, and NO in two groups before and after treatment were compared. Results After treatment, the efficacies in the control and treatment groups were 76.67% and 90.67%, respectively, and there were differences between two groups (P < 0.05). After treatment, systolic and diastolic blood pressure, hs-CPR, and ET in two groups were significantly reduced, while NO in two groups were significantly increased, and the difference was statistically significant in the same group (P < 0.05). And these indicators in treatment group improved better than those in the control group, with significant differences between two groups (P < 0.05). Conclusion Atorvastatin combined with candesartan cilexetil has clinical curative effect in treatment of primary hypertension, and can improve endothelial function and inflammatory response, which is worthy of further promotion and application in clinic.