目的 探索银杏叶提取物注射液联合神经节苷脂治疗缺血性脑血管病的临床疗效.方法 选取2013 年9 月-2014年12 月滨州医学院烟台附属医院收治的缺血性脑血管病患者98 例,随机分为对照组和治疗组,每组各49 例.对照组患者静脉滴注单唾液酸四己糖神经节苷脂钠注射液,60 mg 加入250 mL 生理盐水中,1 次/d.治疗组在对照组基础上静脉滴注银杏叶提取物注射液,20 mL 加入500 mL 生理盐水中,1 次/d.两组患者均连续治疗14 d.治疗后,观察两组的临床疗效,同时比较两组患者血液流变学指标、NIHSS 评分和Barthel 指数的变化.结果 治疗后,对照组和治疗组的总有效率分别为75.51%、89.80%,两组总有效率比较差异有统计学意义(P< 0.05).治疗后,两组患者全血黏度、血浆黏度、纤维蛋白原、红细胞压积、NIHSS 评分均较治疗前显著降低,Barthel 指数升高,同组治疗前后差异有统计学意义(P< 0.05),治疗后,治疗组这些血液流变学指标的改善程度优于对照组,两组比较差异具有统计学意义(P< 0.05).结论 银杏叶提取物注射液联合神经节苷脂治疗缺血性脑血管病疗效显著,可促进神经功能修复,提高患者生活质量,具有一定的临床推广应用价值.

Objective To explore the clinical effect of Extract of Ginkgo biloba Leaves Injection combined with ganglioside in treatment of ischemic cerebrovascular disease. Methods Patients (98 cases) with ischemic cerebrovascular disease in Yantai Affiliated Hospital of Binzhou Medical University from September 2013 to December 2014 were randomly divided into control and treatment groups. Each group had 49 cases. Patients in control group were iv administered with Sodium Monosialotetrahexosylganglioside Injection (60 mg added in 250 mL physiological saline), once daily. Patients in treatment group were iv administered with Extract of Ginkgo biloba Leaves Injection on the basis of the control group (20 mL added in 500 mL physiological saline), once daily. Patients in two groups were treated for 14 d. After treatment, the efficacy was evaluated, the changes of blood rheology indexes, NIHSS score and Barthel index in two groups were compared. Results After the treatment, the efficacies in the control and treatment groups were 75.51% and 89.80%, respectively, and there were differences between two groups (P < 0.05). After treatment, the whole blood viscosity, plasma viscosity, fibrinogen, erythrocyte deposited, and NIHSS score in two groups were significantly reduced, and Barthel index was elevated, and the difference was statistically significant in the same group (P < 0.05). And these indicators in the treatment group improved better than those in the control group, with significant difference between two groups (P < 0.05). Conclusion Extract of Ginkgo biloba Leaves Injection combined with ganglioside has curative effect in treatment of ischemic cerebrovascular disease, and can promote restoration of the nerve function, also can improve patients life quality, which has a certain clinical application value.