目的 研究普罗布考联合阿魏酸哌嗪片治疗糖尿病肾病的临床疗效。方法 选择2012年3—2014年9月在天津市滨海新区大港医院收治的糖尿病肾病患者80例,随机分为对照组和治疗组,每组各40人。所有患者均给予糖尿病肾病的常规治疗。在此基础上,对照组餐后30 min口服阿魏酸哌嗪片,4片/次,3次/d。治疗组口服普罗布考片,4片/次,2次/d,阿魏酸哌嗪片的用法用量同对照组。两组均连续治疗12周。比较两组的临床疗效,同时比较两组治疗前后胱抑素C(Cys C)、高敏C反应蛋白(hs-CRP)、转换生长因子β₁(TGF-β₁)、尿微量白蛋白排泄率(UAER)、血清肌酐(Scr)、丙二醛(MDA)、血尿素氮(BUN)、尿β₂微球蛋白(β₂-MG)变化情况。结果 对照组和治疗组总有效率分别为72.5%、87.5%,两组比较差异有统计学意义(P < 0.05)。治疗后,两组各观察指标均有所改善,其中Cys C、hs-CRP、TGF-β₁、UAER、SCr、MDA、BUN、β₂-MG显著降低,同组治疗前后比较差异有统计学意义(P < 0.05);且治疗组这些观察指标的改善程度优于对照组,两组比较差异有统计学意义(P < 0.05)。结论 普罗布考联合阿魏酸哌嗪片治疗糖尿病肾病具有较好的临床疗效,可以有效抑制炎症发生过程、减轻蛋白尿,为糖尿病肾病的治疗提供了新方法。

objective To investigate the clinical effect of probucol combined with Piperazine Ferulate Tablets in treatment of diabetic nephropathy. Methods The patients with diabetic nephropathy (80 cases) of Dagang Hospital of Tianjin Binhai New Area from March 2012 to September 2014 were randomly divided into control and treatment groups, and each group had 40 cases. All patients were given conventional treatment of diabetic nephropathy. The patients in the control group were po administered with Piperazine Ferulate Tablets 30 min after meal, 4 tablets/time, three times daily. The patients in the treatment group were po administered with Probucol Tablets, 4 tablets/time, twice daily, and the usage and dosage of Piperazine Ferulate Tablets were the same as the control group. The patients in two groups were treated for 12 weeks. After treatment, the efficacy was evaluated, and the changes of Cys C, hs-CRP, TGF-β₁, UAER, SCr, MDA, BUN, and β₂-MG were compared. Results The efficacies in the control and treatment groups were 72.5% and 87.5%, respectively, and there were differences between two groups (P < 0.05). After treatment, Cys C, hs-CRP, TGF-β₁, UAER, SCr, MDA, BUN, and β₂-MG were significantly reduced, and the difference was statistically significant in the same group (P < 0.05). And these indicators in treatment group improved better than those in the control group, with significant difference between two groups (P < 0.05). Conclusion Probucol combined with Piperazine Ferulate Tablets has the good clinical effect in treatment of diabetic nephropathy, and can effectively restrain the inflammation process, while can reduce proteinuria, which provides a new way for the treatment of diabetic nephropathy.