目的 观察递法明片改善高度近视弱视患儿的临床疗效和安全性.方法 选取2012年10月—2013年10月深圳市眼科医院收治的高度近视弱视患儿200例,随机分为治疗组和对照组,每组各100例.治疗组口服递法明片,1片/次,2次/d.对照组口服淀粉片1片/次,2次/d.两组均连续用药6个月.观察两组治疗后3、6个月、随访6个月视力、屈光度、眼轴、角膜屈光力、角膜厚度等的变化.结果 治疗6个月、随访6个月后,治疗组患儿平均视力得到提高,与治疗前比较差异有统计学意义(P<0.05),对照组治疗前后视力差异无统计学意义;治疗6个月、随访6个月后,治疗组视力优于对照组,两组比较差异有统计学意义(P<0.05).治疗6个月、随访6个月后,治疗组屈光度、眼轴、角膜厚度均较治疗前有很多改善,治疗前后差异有统计学意义(P<0.05);且治疗组这些指标优于对照组,两组比较差异有统计学意义(P<0.05).随访6个月后,对照组屈光度、眼轴、角膜厚度较治疗前有所增长,治疗前后差异有统计学意义(P<0.05).结论 递法明片能明显改善高度近视弱视患儿的视力,降低屈光度、眼轴及角膜厚度,对高度近视弱视患儿有一定的疗效.

Objective To explore the efficacy of Difaming Tablets in improvement of high myopia and amblyopia of children. Methods Patients (200 cases) with high myopia and amblyopia of children from October 2012 to October 2013 in the Ophthalmology Hospital of Shenzhen City were randomly divided into treatment (100 cases) and control (100 cases) groups. The patients in the treatment group were po administered with Difaming Tablets, one tablet/time, twice daily. The patients in the control group were po administered with Starch Tablets, one tablet/time, twice daily. The patients in the two groups were treated for six months. The changes of eyesight, diopter, eye axis, corneal refractive power, and corneal thickness in the two groups after the treatment of 3, 6 months, and followed up for 6 months were observed. Results The average eyesight in the treatment group was improved after the treatment of 6 months, and followed up for 6 months, and the differences were statistically significant before and after the treatment in the same group (P < 0.05). The eyesight in the control group was no statistically significant difference before and after the treatment. The eyesight in the treatment group was better than that in control group after the treatment of 6 months, and followed up for 6 months, with the significant difference between the two groups (P < 0.05). The diopter, eye axis, and corneal thickness in the treatment group were improved after the treatment of 6 months, and followed up for 6 months, and the differences were statistically significant before and after the treatment in the same group (P < 0.05). These indicators in the treatment group were better than those in the control group, with the significant difference between the two groups (P < 0.05). The diopter, eye axis, and corneal thickness in the control group were increased followed up for 6 months, and the differences were statistically significant before and after the treatment in the same group (P < 0.05). Conclusions Difaming Tablets can obviously improve the eyesight of high myopia and amblyopia of children, and can reduce the diopter, eye axis, and corneal thickness, which has the certain curative effect for high myopia and amblyopia of children.

深圳市科技计划项目(201303101)