目的 对2010-2013年中国人民解放军海军总医院156例左氧氟沙星不良反应（ADR）报告进行回顾性分析，探讨左氧氟沙星不良反应出现的时辰及规律，从而为不同时间的合理用药积累依据。方法 对4 141例住院患者病历进行回顾性分析，收集左氧氟沙星不良反应出现的时辰、严重程度和临床表现，并进行圆分布资料的统计学分析。结果 左氧氟沙星不良反应以戌时发生率为最高，达2.86%，高于其他时辰，差异具有统计学意义（Watson-William F=17.523，P=0.000）；对不同时辰不良反应严重程度分析发现，戌时和子时重度所占比例达27.27%、25.00%，严重程度较高，与其他时辰相比差异具有统计学意义（Ridit Z=9.321，P=0.000）；不同时辰不良反应临床表现不同。结论 左氧氟沙星不良反应具有时间特异性，这对于临床用药具有指导意义。

Objective One hundred and fifty-six cases with adverse drug reaction (ADR) by Levofloxacin in Navy General Hospital of PLA were analyzed retrospectively from 2010 to 2013, in order to investigate the occurrence time and regularity of adverse reaction about Levofloxacin, resulting in the accumulation of the evidence for rational use of drugs in different time. Methods The medical record of 4 141 cases for hospitalized patients were analyzed retrospectively, the hour, severity, and clinical manifestations were collected,, and the data were analyzed by circular distribution. Results The incidence rate of ADR for Levofloxacin in the period of the day from 7 pm to 9 pm was up to 2.86%, the difference was statistically significant to other times (Watson-William, F=17.523, P=0.000). The severity analysis found, severe accounted for 27.27% and 25% in the period of the day from 7 pm to 9 pm and the one from 11 pm to 1 am, serious degree was higher than those at the other time (Ridit, Z=9.321, P=0.000). The ADR in clinical manifestations was different in different time, and the difference was statistically significant. Conclusion The ADR of Levofloxacin has temporal specificity, which is of guiding significance for clinical medication.