目的 探讨聚甲酚磺醛联合重组人干扰素α-2a在微波治疗宫颈炎中的临床疗效。方法 选取2011年1月-2014年1月在三亚市吉阳镇卫生院治疗的宫颈炎患者80例，随机分为治疗组（40例）和对照组（40例）。对照组患者采用微波治疗，术后第2天起应用重组人干扰素α-2a治疗，阴道上药，1粒/次，1次/d。治疗组于术后第2天给予浸有聚甲酚磺醛的消毒纱布敷于宫颈表面，1次/d，其余同对照组。两组均连续治疗6 d。观察两组患者的临床疗效，同时比较两组患者治疗前后铜蓝蛋白活力、IL-2水平的变化。结果 治疗组和对照组的总有效率分别为100.0%、97.5%，两组比较差异有统计学意义（P<0.05）。治疗后，两组患者铜蓝蛋白活力和IL-2水平均较治疗前显著降低，同组治疗前后差异有统计学意义（P<0.05）。治疗后，治疗组这两项检测指标均显著低于对照组，两组比较差异有统计学意义（P<0.05）。结论 聚甲酚磺醛联合重组人干扰素α-2a在微波治疗宫颈炎中有较好的临床疗效，可以更好的改善临床症状和降低炎症反应，值得临床推广应用。

Objective To observe the clinical efficacy of policresulen combined with polyethylene glycol interferon α-2a in the microwave treatment of cervicitis. Methods Patients (80 cases) with cervicitis in Jiyang Township Health Centers of Sanya City from January 2011 to January 2014 were randomly divided into treatment (40 cases) and control (40 cases) groups. The patients in the control group were treated by microwave, and they were given polyethylene glycol interferon α-2a in vagina from the second day after the microwave treatment, 1 grain/time, once daily. The patients in the treatment group were treated with sterile gauze leaching with policresulen on the surface of the cervix, once daily, and other treatment was the same as the control group. The total clinical efficacy was observed, including the changes of copper blue protein activity and IL-2 level in the two groups before and after the treatments were compared. Results The total effective rates of patients in the treatment and control groups were 100.0% and 97.5%, respectively, with the significant difference between the two groups (P < 0.05). After the treatment, copper blue protein activity and IL-2 level were lower than those before the treatment in the two groups, and the differences were statistically significant in the same group before and after the treatment (P < 0.05). After the treatment, the two measurement indexes in the treatment group were significantly lower than those in the control group, with the significant difference between the two groups (P < 0.05). Conclusion Policresulen combined with polyethylene glycol interferon α-2a has a good clinical efficacy in the microwave treatment of cervicitis, and can better improve the clinical symptoms and reduce inflammation, which is worthy of clinical popularization and application.

国家自然科学基金资助项目（30872743）