目的 评价宝鸡市中心医院临床药师干预骨科Ⅰ类切口手术预防性应用抗菌药物的效果。方法 选取宝鸡市中心医院骨科2011年9月-12月（干预前组）和2013年9月-12月（干预后组）出院的骨科Ⅰ类切口手术病历，进行统计、分析。结果 通过临床药师干预，医院骨科Ⅰ类切口手术抗菌药物使用率显著下降，用药时机和疗程合理性显著提高，规范了抗菌药物品种选择，同时使患者的治疗费用显著降低。结论 通过临床药师的干预可显著提高骨科Ⅰ类切口手术预防性抗菌药物的合理应用水平，同时降低患者的治疗费用。

Objective To assess the effect of antibiotics used for the intervention on the surgical prevention of type I incision in Orthopedics Department of Baoji Central Hospital. Methods The discharged cases of patients undergoing type I incision orthopedic surgery in Baoji Central Hospital from September to December 2011 were selected as control group, and the same cases from September to December 2013 were selected as intervention group. The data conducted were statistically collected and analyzed. Results Through the intervention, the usage rate of antibiotics decreased significantly, while the rationality of the time and the course of using antibiotics improved. The variety choice of antibiotics was more regulated, and the cost of the treatment decreased. Conclusion Through the intervention of clinical pharmacist, the rationality of antibiotic usage for type I incision on surgical prevention in Orthopedics Department improves and the patient's cost used for the treatment decreases.

陕西省卫生厅卫生科研基金项目（2010H42）