药用辅料是药物制剂的基础材料和重要组成部分，在制剂剂型和生产中起关键作用。随着药用辅料生产技术的迅速发展，具有低吸湿性、对原辅料和人体惰性、优异的压片性能与口感良好的优良辅料正在口服固体制剂的开发中被越来越多地关注。从经济性与技术性评价两方面分析了乳糖、纤维素衍生物、磷酸盐、甘露醇等主流固体制剂填充与黏合剂的特点，以便为口服固体制剂中药用辅料的筛选提供科学依据。

Pharmaceutical excipients are essential materials and important parts in pharmaceutical preparations. They play a key role in dosage forms and pharmaceutical industry production. Along with the rapid development of the production technology for pharmaceutical excipients, the pharmaceutical excipients with low hygroscopicity, inertness to raw material and human, good compressibility and good taste are becoming more and more popular in the oral solid preparations. The major excipients for oral solid preparations such as lactose, cellulose derivatives, phosphates and mannitol were evaluated both economically and technically in order to offer the scientific basis for the selection of pharmaceutical excipients in oral solid preparations.