摘 要：目的 对圆滑番荔枝种子氯仿部分的化学成分进行研究。方法 运用正反相硅胶、Sephadex LH-20凝胶及制备高效液相等色谱技术进行分离纯化，并根据理化性质和波谱数据鉴定化合物的结构。结果 分离得到13个化合物，分别鉴定为去乙酰紫玉盘素（1）、去乙酰异紫玉盘素（2）、泡泡树新素（3）、泡番荔枝辛（4）、毛曲番荔枝素（5）、4-desoxycherimolin-2（6）、atemotetrolin（7）、毛叶番荔枝素-2（8）、刺果番荔枝素B（9）、glabrin A（10）、邻苯二甲酸二丁酯（11）、番荔枝五醇C（12）、蔗糖（13）。结论 其中化合物7和12为首次从该植物中分离得到，化合物11和13为首次从该属植物中分离得到。

Abstract: Objective To study the chemical constituents in chloroform fraction from the seeds of Annona glabra. Methods The compounds were isolated by silica gel, reverse phase C18 silica gel, Sephadex LH-20 column chromatographies and pre-HPLC. Their structures were identified on the basis of physicochemical properties and spectroscopic data. Results Thirteen compounds were isolated and identified as desacetyluvaricin (1), 4-deoxyasimicin (2), asimicin (3), bullatacin (4), motrilin (5), 4-desoxycherimolin-2 (6), atemotetrolin (7), cherimolin-2 (8), muricatetrocin B (9), glabrin A (10), dibutyl phthalate (11), annopentocin C (12), and sucrose (13). Conclusion Compounds 7 and 12 are isolated from this plant for the first time, and compounds 11 and 13 are isolated from this genus for the first time.

科技部“重大新药创制”科技重大专项（2009ZX09103-390）