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[摘要]
目的 研究连续iv给予丹红注射液对SD大鼠产生的亚慢性毒性作用。方法 SD大鼠80只,雌雄各半,随机分为对照组和丹红注射液600、200、60 mg/kg剂量组,每组20只,连续iv给药13周,以其体质量、血液生化学、血液学、脏器相对质量、组织病理学检查为指标,全面评价其对大鼠的毒性作用。结果 丹红注射液600 mg/kg组大鼠体质量增长明显延缓,肾功能指标(BUN、Cr)明显增加,组织病理学检查表明肾脏发生病变。结论 iv给予丹红注射液600 mg/kg对大鼠有明显的肾脏毒性。
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[Abstract]
Objective To investigate the subchronic toxicity of Danhong Injection in rats by continuous iv injection. Methods Eighty SD rats (males and females) were randomly devivided into control group and Danhong Injection in 3 different dosage groups (600, 200, and 60 mg/kg, 20 in each group). The rats were administered with Danhong Injection by continuous iv injection for 13 weeks. The body weight, blood biochemistry, hematology, viscera relative weight, and histopathology were measured for the overall toxicity assessment. Results The normal rats administered with Danhong Injection (600 mg/kg) significantly reduced the growth of body weight and showed abnormal escalation of the levels of urea nitrogen (BUN), creatinine (CR). Pathological changes of kidney were found by histopathological examination. Conclusion Danhong Injection with dosage of 600 g/kg has the significant toxicity on kidney by iv injection.
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