目的 观察异甘草酸镁注射液治疗重症肝炎的临床疗效。方法 选取南京市第二医院2008年12月—2013年3月149例重症肝炎患者，随机分为治疗组（83例）和对照组（66例），治疗组给予异甘草酸镁注射液150 mg加入5%～10%葡萄糖注射液中静脉滴注，1次/d；对照组给予复方甘草酸苷注射液160 mg加入5%～10%葡萄糖注射液中静脉滴注，1次/d；治疗期间，两组还同时服用了保肝、抗病毒的药物，两组服用剂量和方法均相同，疗程均为4周。治疗结束后检测两组患者肝功能、凝血功能等指标变化。结果 与治疗前相比，两组患者治疗后的肝功能指标均有明显改善，治疗组丙氨酸氨基转移酶（ALT）、天门冬酸氨基转移酶（AST）明显低于对照组（P＜0.05）；两组患者治疗后的血清总胆红素（TB）、直接胆红素（DB）均有明显降低（P＜0.05）；治疗组患者治疗后凝血酶原时间（PT）指标有明显改善（P＜0.05）。结论 异甘草酸镁注射液治疗重症肝炎有较好疗效，可以改善患者的肝功能和凝血功能，值得临床推广应用。

Objective To observe the clinical effects of Magnesium Isoglycyrrhizinate Injection (MII) on serious hepatitis. Methods A tatal of 149 patients of serious hepatitis patients from The Second Hospital of Nanjing during December, 2008 to March, 2013 were randomly divided into treatment and control groups. The 83 serious hepatitis sufferers were treated with 150 mg MII added into 250 mL 5%—10% glucose injection liquid, other 66 sufferers as control group were treated with 160 mg Compound Glycyrrhizin Injection added into 250 mL 5%—10% glucose injection liquid, iv dripping once daily for 4 weeks. Drugs for protecting liver, antiviral were taken with the same dosage and the methods were the same for two groups. When the treatment was over, the practical effects were analyzed, such as liver function indexes and blood coagulation parameters. Results After treatment, the liver function index was significantly improved. The levels of alanine aminotransferase (ALT) and aspartate aminotransferase (AST) in treatment group were significantly lower than those in the control group (P < 0.05). There was a significant decrease of total bilirubin (TB) and direct bilirubin (DB) in two groups after treatment (P < 0.05). There were significant differences of PT index in treatment group (P < 0.05). Conclusion The blood coagulation and liver function index could be improved after treatment with MII in serious hepatitis sufferers, and there are few side reactions happened. It is worth for clinical use.