目的 研究黄芪甲苷衍生物他司曲洛对实验大鼠心衰模型的改善作用。方法 将实验大鼠冠脉前降支结扎导致心肌梗死，制造慢性心衰模型，动物分为假手术组、模型组、受试药组、阳性对照组，采用累积给药法，研究他司曲洛的正性肌力效应，根据+LVdp/dtmax确定受试药与阳性药作用的等效剂量（ED15）、中毒量、相对安全指数；采用等效剂量法，各给药组连续3 d静脉输注给药，通过血流动力学、彩色多普勒超声心动图、血气分析，以及肺水肿测定，研究各药物短期治疗心衰大鼠的作用效果及特点。结果 他司曲洛的最大效应剂量为2 mg/kg，可产生25%的最大效应。在等效剂量下，他司曲洛静脉输注给药3 d，可明显增加-dp/dtmax，降低LVEDP，降低A峰值，增加E/A比值，并可明显增加血氧分压与血氧含量，可明显减轻肺组织水肿。结论 他司曲洛对实验大鼠心衰治疗具有良好的效果，可达到部分正性肌力药物的作用强度，并可改善心衰大鼠心脏的舒张功能，减轻肺水肿，改善心衰时的呼吸症状。

Objective To study the effect of astragaloside IV derivative tasiquluo used in the treatment of heart failure in experimental rat model. Methods To establish the congestive heart failure (CHF) in rats induced by ligation of the coronary artery. The animals were divided into Sham, model, teste, and positive control groups. Cumulative medication was used to study the positive inotropic effects of tasiquluo. The equivalent dosage (ED15), toxic dosage, and relative safety index were determined according to +LVdp/dtmax. Each group was iv administered with the equivalent dosage for 3 d. The effects and features in the treatment of the heart failure in rats for the short term were investigated by hemodynamics, color Doppler ultrasound echocardiogram, blood gas analysis, and pulmonary edema determination. Results The maximum effective dosage of Tasiquluo was 2 mg/kg, and 25% of the maximum effect could be generated. With ED15 iv infusion of tasiquluo for 3 d, the -LVdp/dtmax was significantly increased and the LVEDP was reduced. While the value of A peak lowered and E/A ratio increased, arterial blood oxygen pressure and oxygen content increased. At the same time, the edema of the lung tissue was relieved. Conclusion Tasiquluo has the good effects on experimental rat model with heart failure, and the drug could reach the positive inotropic effects to some extent. In addition, Tasiquluo could improve the cardiac diastolic functions, reduce the pulmonary edema, and improve the respiratory symptoms in rats with heart failure.