目的 制备氯氮平口腔崩解片，优化处方工艺。方法 以崩解时限、硬度、片面情况和口感为考察指标，采用正交设计法对处方进行筛选，确定最优处方。结果 湿法制粒压片，每片含交联羧甲基纤维素钠20 mg、甘露醇50 mg、微晶纤维素50 mg和预胶化淀粉25 mg时，所得片剂崩解时限小于1 min，且片剂外观光洁，口感良好。结论 氯氮平口腔崩解片处方符合口腔崩解片的质量要求。

Objective To optimize the formula technology of clozapine orally disintegrating tablets. Methods Prescription was optimized by orthogonal test with disintegration time limit, hardness, one-sided situation and taste as indexes. Results Wet granulation tabletting method was carried out. As each tablet contained CMC-Na 20 mg, mannitol 50 mg, MCC 50 mg, and pregelatinized starch 25 mg, and the disintegration time limit was less than 1 min, with smooth appearance, and good taste of tablet. Conclusion The prescription of clozapine orally disintegrating tablets accords with the quality requirements of oral disintegrating tablet.