目的 评价羟苯磺酸钙联合甲钴胺治疗糖尿病周围神经病变（DPN）的疗效。方法 将60例DPN患者随机分为羟苯磺酸钙联合甲钴胺治疗组（n=30）和甲钴胺对照组（n=30），联合治疗组口服羟苯磺酸钙胶囊0.5 g、甲钴胺片0.5 mg；对照组口服甲钴胺片0.5 mg；均每日3次，疗程12周。观察治疗前后患者的腓神经传导速度、神经系统症状及体征变化。结果 治疗组总有效率为93.3%，对照组为63.3%，治疗组在改善运动神经与感觉神经的传导速度、神经系统症状评分及体征评分方面均优于对照组（P＜0.05）。结论 羟苯磺酸钙联合甲钴胺治疗DPN疗效优于甲钴胺单一治疗。

Objective To investigate the curative effects of calcium dobesilate combined with mecobalamin treatment on diabetic peripheral neuropathy (DPN). Methods Sixty patients with DPN were randomly divided into two groups. The treatment group (30 cases) were given calcium dobesilate 0.5 g and mecobalamin 0.5 mg, the control group (30 cases) were only given mecobalamin 0.5 mg, for 3 times one day and 12 weeks a course, respectively. The conductive velocity of nervusperoneus, neurological symptoms, and physical signs were assayed before and after treatment. Results The total effective rate was 93.3% in the treatment group and 63.3% in the control group, conductive velocity of nervusperoneus increased obviously in the treatment group, the neurological symptoms and physical signs improved more apparently in the treatment group than those in the control group. Conclusion The combination of calcium dobesilate and mecobalamin can obviously improve DPN.