内质网应激是一种细胞自我保护性机制的信号反应通路系统，参与许多疾病的生理病理过程。内质网应激参与多种肝脏损伤的发生与发展，包括免疫性肝损伤、病毒性肝损伤、中毒性肝损伤、脂肪性肝损伤等。以内质网应激为切入点，深入探讨内质网应激的分子机制、作用功能，以及内质网应激与各种肝损伤之间的关系。结合临床药物的作用机制，内质网应激可能成为治疗肝脏损伤相关疾病的新靶点。

Endoplasmic reticulum stress (ERS) is a self-protecting regulation system, which is involved in various physiologial and pathological conditions. It is reported that ERS contributes to the occurrence and development of liver injury, including immunological liver injury, viral hepatitis, hepatic adipose infiltration, and hepatotoxicity, and so on. This review is about the mechanism of ERS on hepatocytes in the pathogenesis of a variety of liver injuries. Combining with the clinical studies, ERS might be a novel therapeutic target in liver injury-related disease.

“十一五”科技重大专项（2009ZX09302-002）；中医药行业科研专项（200707008）；中央高校基本科研业务费专项资金（ZJ10115）