目的 考察杠柳毒苷在大鼠体内的组织分布。方法 采用高效液相色谱法测定大鼠静脉注射杠柳毒苷后，组织样品中杠柳毒苷的质量浓度。结果 大鼠iv杠柳毒苷0.74 mg/kg，2、10、20 min后肝中杠柳毒苷的质量浓度分别为（2.447± 0.687）、（0.631±0.272）、（0.292±0.228） μg/g，在肝中最高，其次是肾、心、肺、脾和脑。结论 杠柳毒苷静脉注射后，在大鼠体内分布迅速，主要分布于肝、肾和心中。

Objective To investigate the in vivo tissue distribution of periplocin in rats. Methods An established HPLC-UV method was utilized to determine tissue concentrations of periplocin after iv injection. Results After a single iv dose 0.74 mg/kg to rats, periplocin concentrations in 2, 10, and 20 min was (2.447±0.687), (0.631±0.272), and (0.292±0.228) μg/g in liver, respectively. So the periplocin concentration was maximum in liver followed by kidney, heart, lung, spleen, and brain. Conclusion Periplocin is distributed in rat tissues rapidly following iv injection, and could be mainly distributed in liver, kidney, and heart.

国家自然科学基金资助项目（30973932）；高等学校博士学科点专项科研基金资助项目（20070063001）