摘 要：目的 比较氟伐他汀与辛伐他汀治疗原发性高胆固醇血症的成本和效果。方法 121例患者随机分为A、B两组，A组给以氟伐他汀，每次40 mg,每日1次，B组给以辛伐他汀，每次20 mg，每日1次，2组均连服6周。观察给药期间的不良反应，并进行成本-效果分析。结果 A、B组成本分别为1 250.96、1 357.22元，有效率分别为91.80%、90.00%（P＞0.05）,不良反应发生率分别为5.8%、5.4%（P＞0.05）。结论 氟伐他汀和辛伐他汀均能降低患者血清总胆固醇、甘油三酯和低密度脂蛋白胆固醇水平，疗效相似，且副作用小，安全性良好。从成本角度选择，氟伐他汀为较佳治疗方案。

Abstract: Objective To evaluate the cost-effectiveness of fluvastatin and simvastatin for treatment of primary hyperholesteromia．Methods A total of 121 patients with primary hyperholesteromia were randomly divided into group A and group B．Patients in group A were treated with 40 mg fluvastatin once each day for 6 weeks, and patients in group B were treated with 20 mg simvastatin once each day for 6 weeks．The side effects of fluvastatin and simvastatin were observed，and their cost-effectiveness were analyzed．Results For group A and group B，the cost of each patient was 1250.96 and 1357.22 Yuan per month，the total positive rate was 91.80% and 90.00%（P＞0.05），and the incidence of adverse reactions were 5.8% and 5.4%（P＞0.05）respectively． Conclusion Both fluvastatin and simvatatin can reduce the content of TC，TG，and LDL-C in patients with primary hypercholesterolemia．The two medicines have similar therapeutic effects and good safety，with little side effects．From the perspective of cost-effectiveness，fluvastatin is superior to simvatatin for treatment of primary hyperholesteromia．

中国检验检疫科学研究院院长基金项目(食品添加剂安全风险评估研究)；质检总局课题(2009IK310)