摘 要：目的 观察至生胶囊治疗中晚期食管癌的临床疗效。方法 将48例中晚期食管癌患者随机分为2组，每组24例，均用PP方案化疗，治疗组加服至生胶囊，每次2粒，每日2次。结果 治疗组临床症状，生活质量，疗效，不良反应均优于对照组（P＜0.05）。结论 至生胶囊联合化疗治疗中晚期食管癌，可显著改善症状，提高患者的生存质量。

Abstract: Objective To observe the clinical effects of Zhisheng Capsule combined with chemotherapy on patients with middle or advanced stage esophageal cancer．Methods A total of 48 patients with middle or advanced stage of esophageal cancer were randomly divided into two groups．Patients in both groups were treated by using PP program. In addition，patients in treatment group also took Zhisheng Capsule once 2 capsules for twice a day．Results In treatment group，the clinical symptoms and life quality of patients were improved compared with those of control group，the clinical efficacy was better，and toxic reactions were less（P＜0.05）．Conclusion Zhisheng Capsule，if combined with chemotherapy，can improve significantly the symptoms and life quality in the treatment of middle or advanced stage of esophageal cancer．

河南省科技厅科技公关课题（豫科计082102310017）