炎症是机体抵抗外界刺激的防御反应，也是促使多种疾病发生的病理基础。刺芒柄花素是一种天然异黄酮类化合物，对炎症相关疾病有着显著防治作用，如抗神经系统、呼吸系统、消化系统、肾脏、皮肤等，通过抑制炎症因子释放、调控炎症相关通路、改善机体氧化应激水平等途径发挥其拮抗炎症作用。总结了刺芒柄花素防治炎症相关疾病的研究进展，以期为刺芒柄花素的临床应用和功能开发提供参考。

Inflammation is a defense response of the body to external stimuli, but it is also a pathological basis for the occurrence of many diseases. Formononetin is a natural isoflavone compound. Formononetin has significant preventive and therapeutic effects on inflammation-related diseases, such as anti-neurological system, respiratory system, digestive system, kidney, skin, etc. Formononetin exert their anti-inflammatory effects by inhibiting the release of inflammatory factors, regulating inflammation related pathways, and improving oxidative stress levels in the body. This article summarizes the research progress on the prevention and treatment of inflammation related diseases with formononetin, in order to provide reference for the clinical application and functional development of formononetin.

R965;R975

湖南省卫健委基金资助项目（20201932）；湖南省重点实验室基金资助项目（2023TP1014）